Evidence map›Paper›PMID 41051710›Full record

ReviewAdvances in neurobiology2025

Monoamine Transporters in Drugs of Abuse: Insights from Fast Scan Cyclic Voltammetry.

Shanna B Samels, Pelin Yuksel, Rodrigo A España

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Hypocretin receptor 1 blockade early in abstinence prevents incubation of cocaine seeking and normalizes dopamine transmission.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shanna B SamelsDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Pelin YukselDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
Rodrigo A EspañaDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA. rae39@drexel.edu.

Funding

Involvement of hypocretin-orexin in the regulation of dopamine signaling and reinforcement processes in femalesR01DA031900 · NIDA · DREXEL UNIVERSITY · PI ESPAÑA, RODRIGO A. · 2013 to 2022
$3.6M
Sleep Disturbances During Cocaine Abstinence, Dopamine Adaptations, and Motivation for CocaineR01DA056193 · NIDA · DREXEL UNIVERSITY · PI Rodrigo A. España · 2023 to 2026
$1.8M
NIDA NIH HHS R01 DA031900NIDA NIH HHS R01 DA056193
6 · The paper itself

Abstract

Monoamine transmission is critical for regulating numerous physiological processes, including stress, learning, motor activity, and reward. Over the past few decades, the adoption of fast scan cyclic voltammetry has unveiled an intricate interplay between monoamine release and uptake dynamics, particularly concerning monoamine transporter involvement in reward and reinforcement processes for drugs of abuse. This review discusses how fast scan cyclic voltammetry has revolutionized our understanding of the processes that govern monoamine release and uptake, emphasizing the heterogeneity in transporter function across terminal regions, the influence of autoreceptors on monoamine transmission, and the complex interactions between drugs of abuse and monoamine transporters. While much of the review focuses on what is known about dopamine transporters-due to the wealth of evidence on dopamine transmission-we also emphasize significant gaps in knowledge regarding the serotonin and norepinephrine transporters. Finally, we highlight remaining questions about the dynamic nature of monoaminergic transporter efficiency and suggest new areas of investigation to gain a more comprehensive understanding of the biochemical mechanisms through which monoamine transporters regulate behavior.

Indexed as

Biogenic MonoaminesDopamine Plasma Membrane Transport ProteinsElectrochemical TechniquesIllicit DrugsNorepinephrine Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport ProteinsSubstance-Related DisordersVesicular Monoamine Transport ProteinsAnimalsHumansBiogenic MonoaminesDopamine Plasma Membrane Transport ProteinsIllicit DrugsNorepinephrine Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport ProteinsVesicular Monoamine Transport ProteinsDopamineFast scan cyclic voltammetryHeterogeneityMonoamine releaseMonoamine transportersMonoamine uptakeNorepinephrineSerotoninSubstance abuse

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.