ReviewDiabetes therapy : research, treatment and education of diabetes and related disorders2025
Diabetic Platelets: Pathophysiology, Clinical Significance, and Therapeutic Perspectives.
Review in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Antidiabetic medications and arterial thrombotic risk reduction: a narrative review.Internal and emergency medicine · 2026Review
- Bleeding Events Associated With Continuing Antithrombotic Therapy During Transrectal Ultrasound-Guided Prostate Biopsy: A Propensity Score-Matched Analysis.International journal of urology : official journal of the Japanese Urological Association · 2026Article
- Platelet Indices and Adipokines in Adults with Long-Standing Type 1 Diabetes.Journal of clinical medicine · 2026Article
- The Role of Systemic Immune-Inflammation Index and Prognostic Nutritional Index in Predicting Outcomes of Chinese Patients with Diabetic Foot Ulcers After Moist Exposed Burn Ointment Treatment.International journal of general medicine · 2026Article
- Platelet mitochondria dysfunction in diabetes mellitus: mechanisms and therapeutic implications.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets are crucial for haemostasis and thrombosis. They acquire a distinct prothrombotic and proinflammatory platelet phenotype in individuals with diabetes mellitus, particularly type 2 diabetes mellitus (T2DM). Such platelets in people with diabetes (diabetic platelets) contribute to the pathogenesis of micro- and macro-vascular complications in T2DM. Chronic hyperglycaemia, oxidative stress, advanced glycation end-products (AGEs) and insulin resistance converge to reprogram platelet function at the molecular level. This results in platelet hyperreactivity, enhanced aggregation and a diminished therapeutic response to standard antiplatelet medications. Platelets in people with diabetes play a central role in the development and progression of cardiovascular disease (CVD), the most common cause of mortality in such patients. This manuscript explores the structural and functional changes in platelets in people with diabetes, underlying molecular mechanisms, their role in vascular complications and therapeutic perspectives in patients with diabetes. Also, we introduce the concept of 'haematobolomics' to drive more research in the metabolic profile of platelets in people with diabetes, being a potential avenue for personalised therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.