Evidence map›Paper›PMID 41051681›Full record

Observational studySleep & breathing = Schlaf & Atmung2025

Comparative effects of MAD and CPAP on heart rate in obstructive sleep apnea.

Pasquale Tondo, Mauro Lorusso, Fariba Esperouz, Giuseppina Giannini, Giuseppe Burlon, Matteo Pio Natale, Roberto Sabato, Giulia Scioscia, Monteleone Leonardo, Giulio Trono and 4 more

Abstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pasquale TondoDepartment of Medical and Surgical sciences, University of Foggia, Foggia, Italy.
Mauro LorussoDepartment of Clinical and Experimental Medicine, Dental School of Foggia, University of Foggia, Foggia, Italy. mauro.lorusso@unifg.it.ORCID 0009-0005-4382-5074
Fariba EsperouzDepartment of Clinical and Experimental Medicine, Dental School of Foggia, University of Foggia, Foggia, Italy.
Giuseppina GianniniDepartment of Clinical and Experimental Medicine, Dental School of Foggia, University of Foggia, Foggia, Italy.
Giuseppe BurlonDepartment of Clinical and Experimental Medicine, Dental School of Foggia, University of Foggia, Foggia, Italy.
Matteo Pio NataleDepartment of Medical and Surgical sciences, University of Foggia, Foggia, Italy.
Roberto SabatoInstitute of Respiratory Diseases, Policlinico Riuniti of Foggia, Foggia, 71122, Italy.
Giulia SciosciaDepartment of Medical and Surgical sciences, University of Foggia, Foggia, Italy.
Monteleone LeonardoDepartment of Medical and Surgical sciences, University of Foggia, Foggia, Italy.
Giulio TronoDepartment of Medical and Surgical sciences, University of Foggia, Foggia, Italy.
Michele TepedinoDepartment of Biotechnological and Applied Clinical Sciences, Dental School of L'Aquila, University of L'Aquila, L'Aquila, Italy.
Lucio Lo RussoDepartment of Clinical and Experimental Medicine, Dental School of Foggia, University of Foggia, Foggia, Italy.
Donato LacedoniaDepartment of Medical and Surgical sciences, University of Foggia, Foggia, Italy.
Domenico CiavarellaDepartment of Medical and Surgical sciences, University of Foggia, Foggia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis observational study aimed to compare the effectiveness of mandibular advancement devices (MAD) and continuous positive airway pressure (CPAP) therapy in patients diagnosed with obstructive sleep apnea (OSA), with a specific focus on changes in heart rate parameters.

methodsFifty-two patients treated with MAD were compared with fifty-two patients treated with CPAP. All participants underwent sleep study prior to the initiation of therapy (T0), followed by a control sleep study after a (3-month) predefined treatment period (T1). Changes in cardiac parameters between baseline (T0) and post-treatment (T1) were analyzed both within each group (MAD and CPAP) and between groups. To enhance comparability between patients treated with MAD and those treated with CPAP, a propensity score matching approach was applied based on pre-treatment variables, in order to minimize selection bias and optimize the validity of the between-group comparison.

resultsFor intragroup comparisons, both the MAD and C-PAP groups demonstrated statistically significant reductions in AHI and ODI following treatment (p < 0.001). Additionally, a modest but significant decrease in mean heart rate was noted in both groups (MAD: p = 0.033; CPAP: p = 0.002). For intergroup comparisons, both treatment modalities resulted in a significant reduction in AHI and ODI values. Regarding heart rate parameters, no statistically significant differences were observed between the two groups after treatment for mean HR (p = 0.350), minimum HR (p = 0.602), or maximum HR (p = 0.942).

conclusionThe use of MAD and CPAP leads to significant improvements in heart rate in patients with OSA. However, no significant differences were found between the two treatment modalities in terms of heart rate reduction.

Indexed as

Continuous Positive Airway PressureHeart RateMandibular AdvancementSleep Apnea, ObstructiveAdultAgedFemaleHumansMaleMiddle AgedPolysomnographyCPAPMADObstructive sleep apneaPolysomnography

Identifiers

PMID41051681
PMCPMC12500814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.