Evidence map›Paper›PMID 41051659›Full record

ArticlePulmonary therapy2025

Switching to the Dry Powder Inhaler: Disease Control with a Lower Carbon Footprint.

Christer Janson, Hanna Hisinger-Mölkänen, Lilla Tamasi, Ville Vartiainen, Lauri Lehtimäki

Abstract read
In one paragraph

Article in Pulmonary therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christer JansonRespiratory, Allergy and Sleep Research, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Hanna Hisinger-MölkänenSkin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland. hanna.hisinger-molkanen@hus.fi.
Lilla TamasiDepartment of Pulmonology, Semmelweis University, Budapest, Hungary.
Ville VartiainenIndividualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Lauri LehtimäkiFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDry powder inhalers (DPIs) have a 20-40-fold lower carbon footprint compared to pressurized metered-dose inhalers (pMDIs). Switching from pMDI to DPI is therefore beneficial from an environmental perspective, but many health care professionals are concerned that this may worsen treatment outcomes in asthma and chronic obstructive pulmonary disease (COPD).

methodsWe analyzed patient outcomes and carbon footprints of switching inhaler treatment from pMDI to DPI. We performed a post hoc analysis on clinical outcomes data from a 12-week real-world, non-interventional study of adult patients with asthma or COPD who switched treatment from pMDI to the budesonide-formoterol Easyhaler DPI. Clinical end points included asthma control test (ACT), Mini-Asthma Quality of Life Questionnaire (Mini-AQLQ), lung function tests, and reliever use (asthma), and COPD assessment test (CAT), and modified Medical Research Council dyspnea scale (mMRC) (COPD). In the carbon footprint calculation, we used estimates from the Montreal Protocol for pMDI and for DPI the estimate as reported.

resultsAmong all 237 patients (142 asthma, 95 COPD) by switching their treatment clinical improvements were observed in all the outcome measures (p < 0.001). Furthermore, the need for reliever medication decreased among patients with asthma (p < 0.001). The amount of estimated kg CO

conclusionsOur results show that disease control was maintained among patients with asthma or COPD when they switched from pMDI to DPI, while the carbon footprint of inhaler treatment was reduced.

Indexed as

AsthmaCarbon footprintChronic obstructive pulmonary disease (COPD)Dry powder inhaler (DPI)Easyhaler®Environmental sustainabilityPressurized metered-dose inhaler (pMDI)

Identifiers

PMID41051659
PMCPMC12623521

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.