Isolation, identification, and bioactivity evaluation of endophytic fungi from Ruta graveolens: insights into antimicrobial and antioxidant potential.

Qianyun Hao, Wei Wang, Yanlin He, Chaoyong Cui, Jing Du, Rui Yang

Abstract read

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Article in Folia microbiologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Qianyun HaoCollege of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu, 610059, China.

Wei WangCollege of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu, 610059, China.

Yanlin HeCollege of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu, 610059, China.

Chaoyong CuiCollege of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu, 610059, China.

Jing DuCollege of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu, 610059, China.

Rui YangCollege of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu, 610059, China. yangrui15@cdut.edu.cn.ORCID http://orcid.org/0000-0001-9670-7809

Funding

the Sichuan Science and Technology Program 2022NSFSC0624

6 · The paper itself

Abstract

This study presents a comprehensive investigation of endophytic fungi isolated from Ruta graveolens (Rutaceae), evaluating the bioactivity of their extracts in terms of antimicrobial and antioxidant properties, along with preliminary mycochemical profiles. Twenty-seven isolates were identified using morphological and molecular identification (ITS-rDNA sequencing). Phylogenetic analysis classified them into Alternaria (66.7%, dominant in stems), Chaetomium (25.9%, prevalent in leaves), Achaetomium (3.7%), and Stagonosporopsis (3.7%) genera, demonstrating strong tissue specificity. Antibacterial screening (disk diffusion) of the fungal extracts revealed that 52% (14/27) were active; extracts of S4, S9, S20-2, and L11 showed inhibition against Staphylococcus aureus (inhibition zones, 14.5-15.8 mm at 100 mg/mL), while L5, L10, and L11 extracts exhibited dual activity against both S. aureus and Escherichia coli. Antifungal assays of the extracts identified strains S22, L5, and L12 as effective against phytopathogens Alternaria alternata, Pyricularia grisea, and Curvularia lunata (inhibition rates, 54.2-67.5% at 1 mg/mL). Meanwhile, antioxidant evaluation of the extracts highlighted strain L11 for remarkable DPPH and ABTS radical scavenging (IC

Indexed as

AntimicrobialAntioxidantEndophytic fungiMycochemical analysesRuta graveolens

Identifiers

PMID41051653

DOI10.1016/j.phytochem.2023.113918

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