Evidence map›Paper›PMID 41051638›Full record

ArticleAdvances in therapy2025

The Global Patient Perspective on Uncontrolled Moderate-to-Severe Asthma: Reducing Delays in Diagnosis and Treatment.

Karen Rance, Brenda Young, Gretchen McCreary, Stephanie Williams, Marilyn Urrutia-Pereira, Kristen Willard, Ghulam Mustafa, Purvi Parikh, Tonya Winders, Ruth Tal-Singer

Abstract read
In one paragraph

Article in Advances in therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karen RanceGlobal Allergy and Airways Patient Platform (GAAPP), Hendersonville, TN, USA. krance@gaapp.org.ORCID http://orcid.org/0009-0004-2682-7281
Brenda YoungGlobal Allergy and Airways Patient Platform (GAAPP), Hendersonville, TN, USA.
Gretchen McCrearyGlobal Allergy and Airways Patient Platform (GAAPP), Hendersonville, TN, USA.
Stephanie WilliamsGlobal Allergy and Airways Patient Platform (GAAPP), Hendersonville, TN, USA.
Marilyn Urrutia-PereiraFaculty of Medicine, Federal University of Pampa, Bagé, Brazil.
Kristen WillardGlobal Allergy and Airways Patient Platform (GAAPP), Hendersonville, TN, USA.
Ghulam MustafaCollege of Medicine, Shaqra University, Shaqra, Saudi Arabia.
Purvi ParikhNYU Langone School of Medicine, New York City, NY, USA.
Tonya WindersGlobal Allergy and Airways Patient Platform (GAAPP), Hendersonville, TN, USA.
Ruth Tal-SingerGlobal Allergy and Airways Patient Platform (GAAPP), Hendersonville, TN, USA.

Funding

AstraZeneca 95531573
6 · The paper itself

Abstract

introductionUncontrolled asthma greatly affects quality of life globally and highlights unmet medical needs. Despite advances in treatment and care, many patients still experience delayed diagnoses, poor symptom control, and a reliance on emergency care. The Global Allergy and Airways Patient Platform (GAAPP) surveyed patients with moderate-to-severe uncontrolled asthma to assess their care experiences.

methodsThe GAAPP Time Clock Survey is a cross-sectional, online, multilingual survey of adults living in Brazil, Germany, Italy, Japan, Saudi Arabia, the United Arab Emirates, and the US. The survey examined diagnosis, symptoms, treatment outcomes, challenges in self-management, and timelines for care coordination.

resultsA total of 1401 individuals with self-reported asthma using combination inhaler therapy and experiencing symptoms were enrolled in this study. Among these participants, 56% reported waiting more than 1 month to undergo pulmonary function testing for diagnosis. Additionally, 51% indicated minimal to no improvement in quality of life despite treatment interventions. Difficulties in asthma management were reported by 42% of participants, with some describing the process as difficult or very difficult. Approximately 32% of individuals used daily corticosteroids. Nearly half of the cohort consulted three or more healthcare providers in their pursuit of effective asthma management. Emergency department visits were common, with 50% seeking urgent care for uncontrolled symptoms and 35% requiring hospitalization.

conclusionThis study underscores the importance of policy reforms that prioritize timely diagnosis, shared decision-making, and long-term disease control. Improving outcomes for patients with uncontrolled asthma will require both clinical innovation and structural transformation.

Indexed as

Anti-Asthmatic AgentsAsthmaDelayed DiagnosisAdultAgedCross-Sectional StudiesEmergency Service, HospitalFemaleGlobal HealthHumansMaleMiddle AgedQuality of LifeSelf-ManagementSeverity of Illness IndexYoung AdultAnti-Asthmatic AgentsAsthma diagnosis delaysAsthma management barriersBiologic therapiesGINA step 3Global patient surveyModerate-to-severe asthmaMultidisciplinary asthma careUncontrolled asthma

Identifiers

PMID41051638
PMCPMC12618345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.