Evidence map›Paper›PMID 41051618›Full record

ArticleEuropean journal of nutrition2025

Higher diet quality is associated with a lower prevalence of MASLD and adverse health outcomes: insights from NHANES 2005 to 2020.

Ayesha Sualeheen, Sze-Yen Tan, Robin M Daly, Ekavi Georgousopoulou, Stuart K Roberts, Elena-S George

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Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ayesha SualeheenInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, 3220, Australia.
Sze-Yen TanInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, 3220, Australia.
Robin M DalyInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, 3220, Australia.
Ekavi GeorgousopoulouSchool of Medicine Sydney, University of Notre Dame Australia, Sydney, NSW, Australia.
Stuart K RobertsDepartment of Gastroenterology, Alfred Health, Melbourne, VIC, Australia.
Elena-S GeorgeInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, 3220, Australia. elena.george@deakin.edu.au.ORCID http://orcid.org/0000-0002-1385-2371

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMASLD affects over 30% of the global population increasing the risk of adverse health outcomes. Improvements in diet quality (DQ) may offer a modifiable solution. This study explored the association between DQ and MASLD prevalence, advanced fibrosis, and all-cause mortality.

methodsParticipants from the NHANES U.S. national database were included in the cross-sectional (n = 20,502) and longitudinal (n = 13,161) analysis. DQ assessed using Healthy Eating Index (HEI)-2020, Mediterranean Diet Score (MedDietScore), and Dietary Approach to Stop Hypertension (DASH). MASLD and advanced fibrosis identified by the Fatty Liver Index and NAFLD fibrosis score, respectively. Mortality was ascertained by the National Death Index. Multivariate logistic regression and Cox proportional hazards analysis estimated odds ratios (OR) for MASLD and hazard ratios (HR) for mortality, with 95% confidence interval.

resultsEach 1-SD increase (improvement) in HEI-2020 and MedDietScore was associated with 25% lower likelihood of MASLD, while DASH showed 31% lower likelihood. Each 1‑SD increase in HEI‑2020, MedDietScore, and DASH was associated with lower ORs for advanced fibrosis in the MASLD group: 0.83 (0.74-0.94), 0.84 (0.75-0.95), and 0.78 (0.68-0.89), respectively. Over 9.3 years' median follow‑up, higher DQ was associated with lower all‑cause mortality in the overall population [HEI‑2020: 0.93 (0.86-0.99); MedDietScore: 0.92 (0.86-0.99); DASH: 0.89 (0.83-0.96)], with similar trends in the non‑MASLD group but not in those with MASLD or advanced fibrosis.

conclusionsHigher DQ was associated with lower likelihood of MASLD and advanced fibrosis in U.S. adults and was protective against all-cause mortality in overall and non-MASLD population but not in those with MASLD.

Indexed as

DietDiet, HealthyLiver CirrhosisNutrition SurveysAdultAgedCross-Sectional StudiesDietary Approaches To Stop HypertensionFemaleHumansLongitudinal StudiesMaleMiddle AgedNon-alcoholic Fatty Liver DiseasePrevalenceUnited StatesDASHDiet qualityHEI-2020MASLDMedDietScoreMortality

Identifiers

PMID41051618
PMCPMC12500818

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.