ArticleHead and neck pathology2025
Clear Cell Squamous Cell Carcinoma of Maxillary Alveolus-A Case Report with Diagnostic Pitfalls.
Article in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinicopathological profile of clear cell oral squamous cell carcinoma: a systematic review.Oral and maxillofacial surgery · 2025Pooled it
- Sinonasal low-grade non-intestinal type adenocarcinomas with clear cell features: Clinicopathological and molecular analysis of 6 cases highlighting molecular heterogeneity and identification of a novel ETV6::YEATS4 fusion.Virchows Archiv : an international journal of pathology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClear cell neoplasms are a heterogeneous group of benign and malignant tumours characterized by the presence of clear cells on histological examination. Although uncommon in the head and neck, a wide range of intraoral tumours of varied cellular origins may exhibit clear cell changes. While distinctive histomorphological features often allow accurate diagnosis, extensive clear cell alterations with overlapping patterns can pose significant diagnostic challenges. This paper highlights such challenges and the systematic approach undertaken to establish the final diagnosis.
methodsWe report a rare case of the clear cell variant of oral squamous cell carcinoma (CCSCC) involving the maxillary alveolus in a 58-year-old female. Clinically and histologically, the lesion mimicked odontogenic tumours, salivary gland neoplasms, melanoma, and metastatic lesions of the jaws. Detailed histomorphological assessment, supported by special stains and immunohistochemistry, was performed to reach a definitive diagnosis.
resultsHistopathology revealed epithelial islands of clear cells with features overlapping those of salivary gland and odontogenic tumours, as well as melanoma. Special stains excluded mucoepidermoid carcinoma, calcifying epithelial odontogenic tumour, and metastatic renal cell carcinoma. Immunohistochemistry demonstrated positivity for CK19, EMA and pan-Cytokeratin, with negativity for HMB-45, S100, P63, calretinin & CK10. Examination of deeper sections showed severe epithelial dysplasia with stromal invasion, confirming the diagnosis of CCSCC.
conclusionCCSCC of the oral cavity is an exceptionally rare and diagnostically challenging entity. Accurate diagnosis requires correlation of clinical, imaging, histopathology, and immunohistochemistry. Early recognition is essential, given its aggressive clinical behaviour.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.