Observational studySurgical endoscopy2026
Impact of prior endoscopic or surgical interventions on clinical outcomes after peroral endoscopic myotomy for achalasia.
Observational study in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02770859 (Per-Oral Endoscopic Myotomy), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository
Who cites it
1 citing paper in PubMed.
- Symptom duration is associated with esophageal remodeling in achalasia treated by peroral endoscopic myotomy.Scientific reports · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study is to compare outcomes of POEM for achalasia between those with (PI) or without (NPI) previous disease intervention.
methodsSingle-center retrospective study of consecutive achalasia patients with or without ≥ 1 prior intervention with pneumatic dilation (PD), Heller myotomy (LHM), and/or Botox injection (BTI) who underwent POEM and had ≥ 6-month follow-up. Baseline testing: Eckardt Score (ES), high-resolution manometry (HRM), and functional lumen imaging probe (FLIP) of the esophagogastric junction (EGJ) at 50-mL distention. Between 6 and 12 months after POEM, patients were questioned about daily PPI use and HRM, ES, FLIP, EGD, and pH testing off anti-secretory medications were repeated when possible. Clinical response was defined as follows: ES ≥ 3, EGJ-DI > 2.8 mm
results471 patients (mean: 55 ± 19 yrs; 60% M) with type 1 (17%), 2 (72%) or 3 (11%) achalasia with no prior (n = 325) or a prior (n = 126) intervention were identified. The PI group was older (p < 0.001), had a lower baseline ES (p = 0.03), lower IRP (p = 0.001), higher EGJ-DI (p = 0.001), and a longer POEM procedure time (p = 0.001) compared to the NPI group. Mean overall clinical response by ES (95.3%), IRP (86.7%), and EGJ-DI (86.2%), and daily PPI use (30%), esophagitis (65%), and AET > 6% (49%) were similar between the two groups.
conclusionAchalasia patients with previous LES-directed interventions undergoing POEM are older, have lower ES, lower LES pressure/tone, and require longer POEM times compared to those without previous interventions. Prior intervention does not impact the frequency of clinical response, daily PPI use, esophagitis or post-POEM GERD (ClinicalTrials.gov NCT02770859).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.