Evidence map›Paper›PMID 41051497›Full record

ArticleActa crystallographica. Section C, Structural chemistry2025

Crystallographic and physicochemical characterization of salcaprozoic acid: a structural basis for SNAC-enabled drug delivery systems.

Parag Roy, Paul G Waddell, Rajdeep Dey, Oisín N Kavanagh

Abstract read
In one paragraph

Article in Acta crystallographica. Section C, Structural chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Parag RoySchool of Pharmacy, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom.ORCID 0000-0002-8300-3148
Paul G WaddellSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom.ORCID 0000-0002-7851-7347
Rajdeep DeyDepartment of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, 382 481, India.
Oisín N KavanaghSchool of Pharmacy, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom.

Funding

Action Medical Research/LifeArc GN3039Engineering and Physical Sciences Research Council EP/Y014596/1
6 · The paper itself

Abstract

Salcaprozate sodium (SNAC) is a clinically approved oral permeation enhancer, notably used in the formulation of oral semaglutide. Despite its pharmaceutical importance, the crystallographic information of SNAC or its free acid form, salcaprozoic acid {systematic name: 8-[(2-hydroxyphenyl)formamido]octanoic acid, C

Indexed as

CaprylatesDrug Delivery SystemsCrystallography, X-RayHydrogen BondingMolecular ConformationCaprylatescrystal structuredrug delivery systemHNACoral permeation enhancersalcaprozate sodiumsalcaprozoic acidSNAC

Identifiers

PMID41051497
PMCPMC12587319

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.