Evidence map›Paper›PMID 41051465›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Adiponectin Regulated by Indole-3-Acetic Acid in Paneth Cells Controls Renewal and Differentiation of Gut Stem Cells.

Hang Liu, Xiaomin Su, Juanjuan Wang, Mengli Jin, Yuan Zhang, Rongcun Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Adiponectin Regulated by Indole-3-Acetic Acid in Paneth Cells Controls Renewal and Differentiation of Gut Stem Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hang LiuDepartment of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
Xiaomin SuDepartment of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
Juanjuan WangDepartment of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
Mengli JinDepartment of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
Yuan ZhangDepartment of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
Rongcun YangDepartment of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.ORCID https://orcid.org/0000-0002-5826-4493

Funding

CAMS Innovation Fund for Medical Science (CIFMS2017-12M-2-005)Fundamental Research Funds for the Central University, Nankai University (Grant number 63191724)Ministry of Science and TechnologyMOST | NSFC | - | Government of Shandong Province 91842302State Key Laboratory of Medicinal Chemical BiologyTianjin science and technology commission (18JCZDJC35300)
6 · The paper itself

Abstract

The intestinal epithelium is tightly regulated by intestinal stem cells (ISCs), but the precise mechanisms governing their differentiation remain incompletely understood. We here demonstrate that adiponectin secreted by Paneth cells (PCs) suppresses ISC renewal and differentiation via adiponectin receptor 1 (adipoR1). Genetic ablation of adiponectin in gut epithelial cells (adip

Indexed as

AdiponectinCell DifferentiationIndoleacetic AcidsIntestinal MucosaPaneth CellsStem CellsAnimalsMiceMice, Inbred C57BLMice, KnockoutOrganoidsReceptors, AdiponectinAdiponectinadiponectin receptor 1, mouseindoleacetic acidIndoleacetic AcidsReceptors, Adiponectinadiponectingut epithelial cellsindole‐3‐acetic acidintestinal stem cellsPaneth cells

Identifiers

PMID41051465
PMCPMC12499647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.