Evidence map›Paper›PMID 41051455›Full record

ArticleJournal of autism and developmental disorders2025

Associations Between Altered Auditory EEG Markers and Clinical Impairments in Fragile X Syndrome.

Mélodie Proteau-Lemieux, Inga S Knoth, Saeideh Davoudi, Charles-Olivier Martin, Anne-Marie Bélanger, Valérie K Fontaine, Hazel Maridith Barlahan Biag, Leonard J Abbeduto, Sébastien Jacquemont, David Hessl and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mélodie Proteau-LemieuxDepartment of Psychology, University of Montreal, Montreal, QC, Canada.ORCID http://orcid.org/0009-0007-7789-1170
Inga S KnothAzrieli Research Center of the Sainte-Justine University Hospital, Montreal, QC, Canada.
Saeideh DavoudiAzrieli Research Center of the Sainte-Justine University Hospital, Montreal, QC, Canada.
Charles-Olivier MartinAzrieli Research Center of the Sainte-Justine University Hospital, Montreal, QC, Canada.
Anne-Marie BélangerAzrieli Research Center of the Sainte-Justine University Hospital, Montreal, QC, Canada.
Valérie K FontaineAzrieli Research Center of the Sainte-Justine University Hospital, Montreal, QC, Canada.
Hazel Maridith Barlahan BiagDepartment of Pediatrics and MIND Institute, University of California Davis School of Medicine, Sacramento, CA, USA.
Leonard J AbbedutoDepartment of Psychiatry and Behavioral Sciences and MIND Institute, University of California Davis School of Medicine, Sacramento, CA, USA.
Sébastien JacquemontAzrieli Research Center of the Sainte-Justine University Hospital, Montreal, QC, Canada.
David HesslDepartment of Psychiatry and Behavioral Sciences and MIND Institute, University of California Davis School of Medicine, Sacramento, CA, USA.
Randi J HagermanDepartment of Pediatrics and MIND Institute, University of California Davis School of Medicine, Sacramento, CA, USA.
Andrea SchneiderDepartment of Pediatrics and MIND Institute, University of California Davis School of Medicine, Sacramento, CA, USA.
François V BolducDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Sarah LippéDepartment of Psychology, University of Montreal, Montreal, QC, Canada. Sarah.lippe@umontreal.ca.

Funding

Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
NICHD NIH HHS P50 HD103526
6 · The paper itself

Abstract

purposeIndividuals with Fragile X syndrome (FXS) manifest clinical impairments in several domains. Previous research has shown that auditory evoked potentials (AEPs), measured using electroencephalogram (EEG), are altered in FXS, but the associations between these alterations and the symptoms observed in FXS have not been thoroughly investigated. The aim of this study was to compare AEP markers between individuals with FXS and neurotypical (NT) controls, with the main purpose of exploring how these markers are related to various clinical symptoms present in FXS.

methodsA passive auditory oddball paradigm was presented. P1, N1, P2, N2, P3 and mismatch negativity (MMN) amplitudes and latencies were compared between 41 children and adults with FXS and 46 age-matched NT controls. Amplitudes and latencies, as well as habituation and change detection effects were compared between the groups using mixed design ANOVAs. Pearson correlations were then performed to explore associations between AEP markers and symptoms in the FXS group.

resultsOur results showed that FXS participants had increased N1, P2 and MMN amplitudes and latencies, as well as lack of habituation and change detection effects compared to NT controls. Our correlational analyses revealed several associations between AEPs and phenotypic manifestations; notably, associations between exaggerated N1 and P2 amplitudes and more severe autistic and ADHD symptoms.

conclusionsThese findings confirm that abnormalities of the N1 and P2 components are robust biomarkers of altered sensory processing in FXS and suggest that these alterations may present a dose-response relation to clinical impairments in FXS.

Indexed as

AEPsBehaviorCognitionEEGFragile X syndromeNeurodevelopment

Identifiers

PMID41051455
PMCPMC13022936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.