Evidence map›Paper›PMID 41051447›Full record

ArticleClinical neuroradiology2025

Endovascular Treatment of Intracranial Aneurysms with TaminoVIA Intracranial Stent System: a Prospective, Multicenter, Randomized, Parallel Positive-controlled, Non-inferiority Trial.

Guoli Duan, Yuhang Zhang, Rui Zhao, Pengfei Yang, Jieqing Wan, Xuebin Hu, Ting Lei, Lei Wang, Ge Gao, Sheng Guan and 9 more

Abstract readEquivalence TrialMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Guoli DuanDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yuhang ZhangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Rui ZhaoDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Pengfei YangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Jieqing WanDepartment of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuebin HuDepartment of Neurosurgery, Union Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China.
Ting LeiDepartment of Neurosurgery, Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China.
Lei WangDepartment of Neurosurgery, Yichang Central People's Hospital, Yichang, China.
Ge GaoDepartment of Neurosurgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Sheng GuanDepartment of Interventional Neuroradiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jing XuDepartment of Neurosurgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.
Shu WanDepartment of Neurosurgery, Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wenfeng FengDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Qingdong GuoDepartment of Neurosurgery, The first Affiliated Hospital of Air Force Medical University, Xi'an, China.
Bo YingDepartment of Neurosurgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Li ZhangDepartment of Neurosurgery, Taihe Hospital of Shiyan City, Hubei, China.
Zhe LiDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Qiang LiDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China. lqeimm@126.com.
Jianmin LiuDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo conduct a comprehensive comparative assessment of clinical performance between the novel TaminoVIA stent and the LVIS stent for endovascular treatment of unruptured intracranial aneurysms (UIAs).

methodsThis prospective, multi-center, randomized, open-label, parallel positive-controlled, non-inferiority trial was conducted by 13 centers in China. Patients with UIAs were randomized in a 1:1 ratio to receive endovascular treatment (EVT) with the TaminoVIA stent or the LVIS stent. The primary outcome was successful occlusion at 6‑month follow-up, assessed by a blinded core laboratory. The non-inferiority boundary was set at 12%. Secondary outcomes included immediate procedural success, recanalization rates, and safety endpoints.

resultsBetween March 2022 and April 2024, 203 patients were enrolled and randomized. Full Analysis Set (FAS) analysis showed a 6-month successful occlusion rate of 89.90% (89/99) in the TaminoVIA stent group, compared to 87.00% (87/100) in the LVIS stent group, with a difference of +2.90% (95% CI, -5.97% to 11.77%; P < 0.01). Immediate occlusion rates were comparable (68.89% vs. 61.54%; P = 0.35), and recanalization rates at 6 months were identical (1.11% vs. 1.10%; P > 0.99). The incidence of severe adverse events (SAEs, 13.13% vs. 15.00%, P = 0.84), device-related complications (2.02% vs. 0%, P = 0.25) and procedure-related SAEs (2.02% vs. 2.00%, P > 0.99) were comparable between the two groups. Both PPS and FAS analyses exceeded the non-inferiority boundary.

conclusionsThe TaminoVIA stent demonstrated non-inferiority to LVIS in both efficacy and safety for IA embolization. These findings support its clinical adoption, though long-term durability requires further validation. CLINICAL TRIAL REGISTRATION NUMBER: ChiCTR2400092436.

Indexed as

Endovascular ProceduresIntracranial AneurysmStentsAdultAgedChinaFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeEndovascular treatmentIntracranial aneurysmRandomized clinical trialsSafetyTaminoVIA stent

Identifiers

PMID41051447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.