ReviewMolecular biology reports2025
Lamin A/C as a biomarker for breast cancer.
Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
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Abstract
Lamin proteins are a type of intermediate filament primarily located in the nucleus. They are classified into two categories: A-type and B-type lamins. Lamin A and lamin C belong to the A-type category and are commonly grouped as Lamin A/C. Diseases related to this protein are generally called laminopathies which have different presentations. Lamin A/C is also involved in cancers specifically breast cancer. Research has shown that changes in lamin A/C expression, particularly its decrease in breast cancer, are associated with various cancer-related features, including altered nuclear shape, mitotic abnormalities, shifts in gene expression, cancer cell migration, and metastasis. This review delivers a complete overview of the findings regarding the association and roles of lamin A/C in breast tumor cells. It highlights the importance and potential clinical applications of this promising biomarker, offering the possibility of using this protein for breast cancer diagnosis and as a prognostic marker for patients with breast cancer.
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