Trial reportThe Journal of infectious diseases2026
The Burden of Surgical Site Infections With Pathogens Presumably Resistant to Perioperative Prophylaxis in Orthopedic Tumor Surgery: Secondary Analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Trial.
Trial report in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundSurgical procedures for malignant bone tumors of the lower extremity are associated with a significant risk of surgical site infection (SSI). Little is known about the microbiology and risk factors for resistant SSIs in this population.
methodsWe describe the microbiological and other characteristics and of SSIs, as well as risk factors for antimicrobial resistance against antibiotics used for perioperative prophylaxis in a secondary analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial population. The PARITY trial assessed the effects of short-term (24 hour) versus long-term (5-day) postoperative antibiotic prophylaxis on the SSI incidence in orthopedic oncology.
resultsSSIs were identified in 96 of 604 patients (15.9%), with ≥1 pathogen isolated in 73 (76.0%). The most common pathogens were coagulase-negative staphylococci (34.4%), Staphylococcus aureus (24.0%), and Enterobacterales (22.9%). The proportions of pathogens with presumed resistance against cephalosporins were similar in the 2 groups (65.9% in the short-term vs 71.9% in the long-term arm; odds ratio [OR], 0.76 [95% confidence interval, .28-2.06]; P = .58). Neutropenia (22.9% vs 4.8%; OR, 5.95 [95% confidence interval, .72-49.45]; P = .06) and initiation of antibiotics >7 days before SSI diagnosis (50.0% vs 34.8%; OR, 1.88 [.68-5.21; P = .22) were numerically but not statistically significantly more common in those with presumed resistance.
conclusionsSSIs due to pathogens presumably resistant to the systemic or local prophylactic agents used are common in patients undergoing reconstruction for bone tumors. The selection of presumably resistant pathogens is not driven by the duration of antibiotic prophylaxis; however, antibiotic-loaded cement was associated with resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.