ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2026
Neural crest-specific disruption of Evc2 provides an animal model to study the temporomandibular joint development and homeostasis in response to jaw loading.
Rafael Correia Cavalcante, Honghao Zhang, Felicia Miranda, Susannah C Midla, Veronique M Lefebvre, Peter X Ma, Lucia H S Cevidanes, Yuji Mishina
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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International journal of molecular sciences · 2026
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8 authors.
Rafael Correia CavalcanteDepartment of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109, United States.ORCID 0000-0001-6466-5165
Honghao ZhangDepartment of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109, United States.
Felicia MirandaDepartment of Orthodontics and Pediatric Dentistry, The University of Michigan, Ann Arbor, MI 48109, United States.
Susannah C MidlaDepartment of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109, United States.
Veronique M LefebvreDepartment of Surgery/Division of Orthopaedic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.
Peter X MaDepartment of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109, United States.
Lucia H S CevidanesDepartment of Orthodontics and Pediatric Dentistry, The University of Michigan, Ann Arbor, MI 48109, United States.
Yuji MishinaDepartment of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109, United States.
Funding
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Quantification of 3D Bony Changes in Temporomandibular Joint OsteoarthritisR01DE024450 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Lucia H Cevidanes · 2013 to 2026
$5.5M
Molecular pathogenesis of craniosynostosis caused by enhanced BMP signalingR01DE020843 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI · 2010 to 2019
$4.9M
Regenerating cranial suture (Jaylynn Jones)R01DE027662 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HATCH, NAN E, MISHINA, YUJI · 2018 to 2022
$2.6M
Temporal regulation of BMP signaling in patterning the tracheal cartilage and pharmacological approaches to prevent tracheomalacia (DivSupp)R01HL162939 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI · 2022 to 2025
$1.6M
Nanofibrous self-gelling microspheres for heart regenerationR01HL139735 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X, WANG, ZHONG · 2019 to 2022
$1.6M
Regenerating Hyaline Cartilage Using Nanofibrous Hollow Microspheres and Synergizing TGF-β and HIFR01AR075770 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI PETER X MA · 2020 to 2026
$1.5M
MicroCT 100S10RR026475 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2010 to 2010
The temporomandibular joint (TMJ), essential for jaw movements, is susceptible to osteoarthritis, impacting a significant portion of the population. This study introduces an innovative genetic mouse model to explore TMJ development, maintenance, and interactions with the mechanical environment. We exploited Evc2/Limbin conditional KO (Evc2 cKO) mice, specifically targeting neural crest cell-derived tissues (Wnt1Cre), to observe TMJ development. Disruption of Evc2 in neural crest cells contributed to morphological changes in the TMJ growth plate cartilage layers, predisposing the joint components to defects. Condyle defective regions presented a unique environment composed of cartilage, bone, stem cells, and an augmented polymorphic layer. Our findings further revealed that the Evc2 cKO mice presented TMJ components degeneration clinically like those observed in human TMJ-osteoarthritis (OA). Mandible condyle gene expression analysis showed augmented expression of general inflammatory and OA markers. Supplying the mice with regular chow worsens the phenotype, but soft chow fed partially rescued both condyle morphology and intra-articular space. The data suggest that changes in the loading environment critically affect the integrity and functionality of the TMJ, with direct implications for its preservation and disease management.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Neural crest-specific disruption of Evc2 provides an animal model to study the temporomandibular joint development and homeostasis in response to jaw loading. · full record | OpenQuestion