Evidence map›Paper›PMID 41051323›Full record

ArticleACS nano2025

Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release.

Tabasom Haghighi, Adrian Najer, Marta Broto, Farah A Dahalan, Alisje Churchyard, Sabrina Yahiya, Mufuliat T Famodimu, Mark Tunnicliff, Aida Abdelwahed, Mayumi Tachibana and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tabasom HaghighiDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
Adrian NajerDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.ORCID 0000-0003-4868-9364
Marta BrotoDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
Farah A DahalanDepartment of Life Sciences, Imperial College London, London SW7 2AZ, U.K.
Alisje ChurchyardDepartment of Life Sciences, Imperial College London, London SW7 2AZ, U.K.
Sabrina YahiyaDepartment of Life Sciences, Imperial College London, London SW7 2AZ, U.K.
Mufuliat T FamodimuDepartment of Life Sciences, Imperial College London, London SW7 2AZ, U.K.ORCID 0000-0002-8852-1040
Mark TunnicliffDepartment of Life Sciences, Imperial College London, London SW7 2AZ, U.K.
Aida AbdelwahedDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
Mayumi TachibanaDivision of Molecular Parasitology, Proteo-science Center, Ehime University, 454 Shitsukawa, Toon, Ehime 791-0295, Japan.
Tomoko IshinoDepartment of Parasitology and Tropical Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Yaw AniwehWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, LG 54 Legon, Ghana.
Gordon A AwandareWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, LG 54 Legon, Ghana.
Almahamoudou MahamarClinical Research Unit of Bougouni-Ouelessebougou, Malaria Research and Training Centre, University of Sciences, Techniques, and Technologies of Bamako, Bamako BP 1805, Mali.
Leen N VanheerDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.
Teun BousemaRadboud Institute for Health Sciences, Radboud University Medical Centre, Geert Grooteplein Zuid 28, 6525GA Nijmegen, Netherlands.
Chris DrakeleyDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.
Alassane DickoClinical Research Unit of Bougouni-Ouelessebougou, Malaria Research and Training Centre, University of Sciences, Techniques, and Technologies of Bamako, Bamako BP 1805, Mali.
William StoneDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.
Jake BaumDepartment of Life Sciences, Imperial College London, London SW7 2AZ, U.K.
Molly M StevensDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.ORCID 0000-0002-7335-266X

Funding

Gates Foundation INV-002098Gates Foundation INV-005735Wellcome Trust
6 · The paper itself

Abstract

Preventing malaria parasite transmission to the mosquito vector is a key elimination challenge that could benefit from a diagnostic test that can identify transmission-competent individuals. Only sexual parasite forms, called gametocytes, which activate into gametes (gametogenesis) upon mosquito uptake or blood sampling are responsible for transmission. Herein, we devised a nanozyme-based immunoassay to detect the

Indexed as

Antigens, ProtozoanMalaria, FalciparumPlasmodium falciparumAnimalsFemaleHumansImmunoassayPrimaquineAntigens, ProtozoanPrimaquinediagnosticmalariananozymePlasmodium falciparumtransmission

Identifiers

PMID41051323
PMCPMC12548336

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.