Evidence map›Paper›PMID 41051313›Full record

ReviewThe Journal of infectious diseases2026

Restoring TB-specific Immunity in Early HIV Infection-the Dual Promise of Early Antiretroviral and TB Preventive Treatment.

Patrick K Moonan, Stephen O Mathew, Jerry W Simecka, Stephen E Weis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Patrick K MoonanCollege of Biomedical and Translational Sciences, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA.ORCID 0000-0002-3550-2065
Stephen O MathewCollege of Biomedical and Translational Sciences, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA.ORCID 0000-0001-5784-224X
Jerry W SimeckaCollege of Biomedical and Translational Sciences, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA.ORCID 0000-0001-8262-3823
Stephen E WeisTexas College of Osteopathic Medicine, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA.ORCID 0009-0004-8447-2327

Funding

Dynamics of TB and MDR TB transmission in areas with high HIV prevalenceR01AI097045 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ZETOLA, NICOLA MARIO · 2011 to 2015
$2.9M
NIAID NIH HHS R01 AI097045
6 · The paper itself

Abstract

Early HIV infection disrupts TB-specific immunity, raising TB risk before CD4 decline. Early ART may help but cannot fully restore function, making tuberculosis preventive treatment indispensable-potentially lifelong-to close immunologic gaps and reduce HIV-associated TB morbidity and mortality.

Indexed as

Anti-HIV AgentsAnti-Retroviral AgentsAntitubercular AgentsHIV InfectionsTuberculosisCoinfectionHumansAnti-HIV AgentsAnti-Retroviral AgentsAntitubercular Agents

Identifiers

PMID41051313
PMCPMC13231459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.