ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress-Related Male Reproductive Dysfunction.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Establishment of Sertoli Cell Lines from Giant Pandas (Animals : an open access journal from MDPI · 2026Article
- Sympathetic signaling activation alleviated acute respiratory distress syndrome via the HDC/SLC7A11 axis in lipopolysaccharide-induced macrophages.Cell death discovery · 2026Article
- Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway.Biomedicines · 2026Review
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Authors and funding
13 authors.
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Abstract
Psychological stress poses a significant threat to male reproduction; however, the underlying molecular mechanisms remain poorly understood. Stress-induced hyperactivation of the sympathetic nervous system triggers the secretion of norepinephrine (NE), a key mediator implicated in various pathophysiological processes. Although NE is linked to male reproductive dysfunction, the precise mechanism remains unclear. Here, it is demonstrated that psychological stress can induce Sertoli cell ferroptosis through NE, which is characterized by iron overload, lipid peroxidation, and altered expression of ferroptosis-related proteins. Blockade of β-adrenergic receptors (β-ARs) with propranolol alleviated stress-induced damage, inhibiting ferroptosis and promoting spermatogenesis. In vitro, selective β
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