Evidence map›Paper›PMID 41051263›Full record

ReviewRheumatology (Oxford, England)2026

Mapping a path forward: addressing disease burden, pathways and solutions in ANCA-associated vasculitis.

Bernhard Hellmich

Abstract readReview
In one paragraph

Review in Rheumatology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Understanding the burden of ANCA-associated vasculitis.Rheumatology (Oxford, England) · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Bernhard HellmichKlinik für Innere Medizin, Rheumatologie, Pneumologie, Nephrologie und Diabetologie, Medius KLINIKEN Kirchheim-Teck & Nürtingen, Akademisches Lehrkrankenhaus der Universität Tübingen, Kirchheim unter Teck, Germany.ORCID 0000-0002-8014-1801

Funding

AstraZenecaVifor Fresenius Medical Care Renal Pharma AG
6 · The paper itself

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a frequently relapsing systemic autoimmune disorder characterized by inflammation and destruction of small- to medium-sized blood vessels resulting in potentially life-threatening organ damage. Of the three AAV subtypes, granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are the most common. The aims of treatment are to rapidly control active disease with induction therapy [typically rituximab (RTX) (the new standard-of-care) or cyclophosphamide alongside glucocorticoids (GC) and avacopan], followed by less aggressive maintenance strategies to reduce the risk of relapse. International and national guidelines for the treatment of GPA/MPA are generally aligned, with all guidelines highlighting a need to reduce treatment-related adverse events through rapid GC tapering and the use of GC-sparing avacopan treatment. Guidelines will continue to evolve as ongoing studies provide new insights into alternative (GC-sparing) treatment options and optimal RTX-based treatment regimens.

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisCost of IllnessCyclophosphamideDrug Therapy, CombinationGlucocorticoidsGranulomatosis with PolyangiitisHumansImmunosuppressive AgentsMicroscopic PolyangiitisPractice Guidelines as TopicRituximabCyclophosphamideGlucocorticoidsImmunosuppressive AgentsRituximabAAVANCA-associated vasculitisAnti-neutrophil cytoplasmic antibodyavacopaninduction therapymaintenance therapytreatment guidelines

Identifiers

PMID41051263
PMCPMC12783590

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.