Evidence map›Paper›PMID 41051254›Full record

ReviewNeuro-oncology2026

Intracranial metastases from solid tumors: Call to action and consensus from the Society for Neuro-Oncology and American Society of Clinical Oncology collaborative.

Akanksha Sharma, Lucy Boyce Kennedy, Amanda E D Van Swearingen, Manmeet S Ahluwalia, Stephen J Bagley, Veronica L Chiang, Caroline Chung, Diana M Cittelly, Mariza Daras, Michael A Davies and 21 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Akanksha SharmaDivision of Neuro-Oncology, Sutter Health/California Pacific Medical Center, San Francisco, California (A.S.).
Lucy Boyce KennedyDepartment of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio (L.B.K.).
Amanda E D Van SwearingenDuke Cancer Institute, Duke University, Durham, North Carolina (A.E.D.V., M.K., C.K.A.).ORCID 0000-0002-4287-9741
Manmeet S AhluwaliaMedical Oncology, Baptist Health South Florida, Miami, Florida (M.S.A.).ORCID 0000-0003-3794-9511
Stephen J BagleyAbramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (S.J.B.).ORCID 0000-0002-7117-0539
Veronica L ChiangDepartment of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut (V.L.C.).ORCID 0000-0003-1882-3876
Caroline ChungDepartment of CNS Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (C.C.).
Diana M CittellyDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado (D.M.C.).ORCID 0000-0002-8392-0800
Mariza DarasDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia (M.D.).ORCID 0000-0002-2613-1709
Michael A DaviesDepartment of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (M.A.D.).
Peter E FecciDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado (P.E.F.).ORCID 0000-0002-2912-8695
Daphne A Haas-KoganDepartment of Radiation Oncology, Mass General Brigham, Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts (D.A.H.-K.).
Jona A Hattangadi-GluthRadiation Medicine and Applied Sciences, University of California, San Diego, California (J.H.-G.).ORCID 0000-0001-8222-606X
Katarzyna J JerzakSunnybrook Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada (K.J.J.).
Michelle M KimDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (M.M.K.).
Rachna MalaniDepartment of Neurosurgery, University of Utah/Huntsman Cancer Institute, Salt Lake City, Utah (R.M.).ORCID 0000-0003-2038-8738
Minesh P MehtaDepartment of Radiation Oncology, Florida International University and Miami Cancer Institute of Baptist Health South Florida, Miami, Florida (M.P.M.).
Nelson S MossDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York (N.S.M.).ORCID 0000-0002-0930-1681
Josh NemanDepartment of Neurological Surgery, University of Southern California, Los Angeles, California (J.N.).ORCID 0000-0002-6337-9615
Don X NguyenDepartment of Medical Oncology, Yale School of Medicine, New Haven, Connecticut (D.X.N.).
Saul J PricemanCenter for Cancer Cellular Immunotherapy Research, University of Southern California, Los Angeles, California (S.J.P.).
Solmaz SahebjamDepartment of Oncology, John Hopkins University School of Medicine, Baltimore, Maryland (S.S.).ORCID 0000-0001-9930-9937
Helen A ShihMass General Brigham Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts (H.A.S.).
Riccardo SoffiettiCandiolo Cancer Institute, FPO-IRCCS, Candiolo, Turin, Italy (R.S.).ORCID 0000-0002-9204-7038
Nancy WangDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (N.W.).
Alexandra ZimmerHematology & Medical Oncology, Oregon Health and Sciences University, Portland, Oregon (A.Z.).
Sarah GoldbergDepartment of Oncology, Yale University School of Medicine, New Haven, Connecticut (S.G.).
Mustafa KhasrawDuke Cancer Institute, Duke University, Durham, North Carolina (A.E.D.V., M.K., C.K.A.).ORCID 0000-0003-3249-9849
Carey K AndersDuke Cancer Institute, Duke University, Durham, North Carolina (A.E.D.V., M.K., C.K.A.).ORCID 0000-0001-9165-4074
Nancy U LinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (N.U.L.).ORCID 0000-0003-2263-5413
SNO/ASCO Brain Metastasis Collaborative Think Tanks

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
Mechanisms of endocrine therapy and radiation synergism to decrease brain metastasesR01CA290813 · NCI · UNIVERSITY OF COLORADO DENVER · PI Diana M. Cittelly · 2024 to 2026
$2.7M
Mechanisms underlying pro-metastatic effects of estrogen in the brain nicheR37CA227984 · NCI · UNIVERSITY OF COLORADO DENVER · PI CITTELLY, DIANA M. · 2018 to 2024
$2.5M
BCRP BC210460NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA290813NCI NIH HHS R37 CA227984NIH HHS R01CA290813NIH HHS R37CA227984The Reiner Family Fund for Breast Cancer Brain Metastases Research
6 · The paper itself

Abstract

Intracranial metastases (ICM), specifically parenchymal brain metastases, remain a major clinical challenge in solid tumor oncology, despite recent advances in cancer therapies which have led to improvements in survival for these patients. Improving outcomes even further in this patient population will require a multi-disciplinary approach, including pre-clinical and translational studies, clinical trials, and studies of patient reported outcomes and quality of life. At the 2023 and 2024 joint Society for Neuro-Oncology (SNO) and American Society of Clinical Oncology (ASCO) CNS Metastases Conferences, two ICM collaborative group think tanks convened, composed of diverse, multi-disciplinary stakeholders, including basic and translational researchers, clinical trialists, and clinicians from academia and the community setting. Here we summarize the key knowledge gaps and consensus recommendations put forth by these two think tanks. Advances in ICM research and improvements in patient outcomes will require close inter-specialty and inter-institutional collaboration between stakeholders, including pre-clinical and translational researchers, clinical investigators, industry, and regulatory bodies.

Indexed as

Brain NeoplasmsMedical OncologyNeoplasmsConsensus Statements as TopicHumansSocieties, Medicalbrain metastasesclinical trialsconsensusintracranial metastasestumor microenvironment

Identifiers

PMID41051254
PMCPMC12979032

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.