Evidence map›Paper›PMID 41051246›Full record

ArticlemBio2025

Self-resistance mechanism to acyldepsipeptide antibiotics in the

Dhana Thomy, Laura Reinhardt, Elisa Liebhart, Mirita Franz-Wachtel, Boris Maček, Peter Sass, Heike Brötz-Oesterhelt

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. ClpP2 modulates ClpXP assembly to promote multiple pathogenic phenotypes inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. ARTS-DB 2.0: an expanded database for target-directed genome mining across bacteria and fungi.Database : the journal of biological databases and curation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dhana Thomy *Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.
Laura Reinhardt *Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.
Elisa LiebhartDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.
Mirita Franz-WachtelCluster of Excellence-Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.
Boris MačekCluster of Excellence-Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.
Peter SassDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-4477-2382
Heike Brötz-OesterheltDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.ORCID 0000-0001-9364-1832

Funding

Deutsche Forschungsgemeinschaft Project-ID 174858087Deutsche Forschungsgemeinschaft Project-ID 390838134Deutsche Forschungsgemeinschaft Project-ID 398967434
6 · The paper itself

Abstract

Clp proteases are ubiquitous in bacteria and play an important role in regulatory proteolysis and in maintaining protein homeostasis within the bacterial cell. They consist of a tetradecameric, proteolytic ClpP core and associated AAA+ Clp-ATPases. The Clp system of

Indexed as

Anti-Bacterial AgentsDepsipeptidesDrug Resistance, BacterialEndopeptidase ClpStreptomycesBacterial ProteinsAnti-Bacterial AgentsBacterial ProteinsDepsipeptidesEndopeptidase ClpADEPClpPClp proteasenatural productsproducer self-protectionStreptomyces hawaiiensis

Identifiers

PMID41051246
PMCPMC12607617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.