ArticleMicrobiology spectrum2025
The antimicrobial metabolite nisin Z reduces intestinal tumorigenesis and modulates the cecal microbiome in Apc
Layan Hamidi Nia, Sara Alqudah, Rachel L Markley, Beckey DeLucia, Viharika Bobba, Judi Elmallah, Ina Nemet, Naseer Sangwan, Jan Claesen
Abstract read
In one paragraphArticle in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Layan Hamidi NiaDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0001-9566-5491 Sara AlqudahDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, Ohio, USA.
Rachel L MarkleyDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, Ohio, USA.
Beckey DeLuciaDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, Ohio, USA.
Viharika BobbaDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, Ohio, USA.
Judi ElmallahDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, Ohio, USA.
Ina NemetDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, Ohio, USA.
Naseer SangwanDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, Ohio, USA.
Jan ClaesenDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0002-0755-7974 Funding
Uncovering aryl polyene biology to identify new drug targets in Gram-negative bacterial pathogensR01AI153173 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI CLAESEN, JAN · 2021 to 2025
$2.0MCleveland Clinic Foundation Seed fundNIAID NIH HHS R01 AI153173NIH HHS AI153173NIH HHS HL16074Prevent Cancer Foundation PCF2019-JC
6 · The paper itselfAbstract
Nisin Z, an antimicrobial metabolite produced by IMPORTANCE: With the increased incidence of colorectal cancer, especially among younger individuals, it is critical to study approaches that help with the prevention and treatment of this debilitating disease. Our study indicates that nisin Z, a bacterially produced peptide antibiotic, decreases the growth of colorectal cancer cells and moderately increases cell death
Indexed as
Anti-Bacterial AgentsCarcinogenesisCecumColorectal NeoplasmsGastrointestinal MicrobiomeNisinAnimalsCell ProliferationDisease Models, AnimalHumansLactococcus lactisMiceMice, Inbred C57BLNF-kappa BAnti-Bacterial AgentsNF-kappa BNisinApcMin/+micecolorectal cancergut microbiotametabolitesNF-κB signalingnisin Z
Identifiers
PMID41051239
PMCPMC12584763
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