Evidence map›Paper›PMID 41051222›Full record

ArticleMolecular pharmaceutics2025

Evaluation of the Antitumor Efficacy of Human Papillomavirus Type 16 E7-Affitoxin in C57BL/6JNifdc Mice Bearing TC-1 Tumors.

Hua Zhu, Zhihui Zhang, Jingwei Ye, Hongshuai Yang, Jingjie Lin, Xinlei Cao, Lifang Zhang, Yubing Chen, Pengfei Jiang

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hua ZhuDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.
Zhihui ZhangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.
Jingwei YeDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.
Hongshuai YangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.
Jingjie LinDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.
Xinlei CaoDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.
Lifang ZhangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.
Yubing ChenDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.
Pengfei JiangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.ORCID 0000-0001-8996-2406

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV) associated cancers pose a significant global health threat, with HPV 16 being the most common causative type. Current treatments often lack specificity and cause severe side effects. In a previous study, we developed an HPV16 E7 targeted therapeutic agent, Z

Indexed as

Antineoplastic AgentsHuman papillomavirus 16Papillomavirus E7 ProteinsUterine Cervical NeoplasmsAnimalsApoptosisCell Line, TumorCell ProliferationFemaleHumansMiceMice, Inbred C57BLPapillomavirus InfectionsXenograft Model Antitumor AssaysAntineoplastic Agentsoncogene protein E7, Human papillomavirus type 16Papillomavirus E7 Proteinsaffitoxinantitumor targeted therapyC57BL/6JNifdc miceHPV16TC-1 tumor

Identifiers

PMID41051222
PMCPMC12587393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.