Evidence map›Paper›PMID 41051206›Full record

ArticlemBio2025

Screening of gene function in cell intoxication by CNF1 links Sec61 translocon to Rac1 GTPase activity.

Eléa Paillares, Nathalie Deboosere, Stéphane Descorps-Declere, Maud Marechal, Daniel Gillet, Caroline Demangel, Amel Mettouchi, Priscille Brodin, Emmanuel Lemichez

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eléa PaillaresDépartement de Microbiologie, Unité des Toxines Bactériennes, Institut Pasteur, CNRS UMR6047, INSERM U1306, Université Paris Cité, Paris, France.ORCID 0000-0003-3701-2956
Nathalie DeboosereUniv. Lille, CNRS UMR 9017, INSERM U 1019, Institut Pasteur de Lille, US 41-UAR 2014-PLBS, CIIL-Center for Immunity and Infection of Lille, Lille, France.
Stéphane Descorps-DeclereInstitut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, France.
Maud MarechalDépartement de Microbiologie, Unité des Toxines Bactériennes, Institut Pasteur, CNRS UMR6047, INSERM U1306, Université Paris Cité, Paris, France.
Daniel GilletDépartement Médicaments et Technologies pour la Santé, Université Paris Saclay, CEA, INRAE, SIMoS, Gif-sur-Yvette, France.
Caroline DemangelInstitut Pasteur, Université Paris Cité, INSERM U1224, Immunobiology and Therapy Unit, Paris, France.
Amel MettouchiDépartement de Microbiologie, Unité des Toxines Bactériennes, Institut Pasteur, CNRS UMR6047, INSERM U1306, Université Paris Cité, Paris, France.ORCID 0000-0003-1453-6482
Priscille BrodinUniv. Lille, CNRS UMR 9017, INSERM U 1019, Institut Pasteur de Lille, US 41-UAR 2014-PLBS, CIIL-Center for Immunity and Infection of Lille, Lille, France.
Emmanuel LemichezDépartement de Microbiologie, Unité des Toxines Bactériennes, Institut Pasteur, CNRS UMR6047, INSERM U1306, Université Paris Cité, Paris, France.ORCID 0000-0001-9080-7761

Funding

Agence Nationale de la Recherche ANR-19-ASTR-0001
6 · The paper itself

Abstract

The CNF1 toxin from extraintestinal pathogenic

Indexed as

Bacterial ToxinsEscherichia coli Proteinsrac1 GTP-Binding ProteinSEC Translocation ChannelsEscherichia coliHumansProtein Processing, Post-TranslationalRNA, Small InterferingSignal TransductionBacterial Toxinscytotoxic necrotizing factor type 1Escherichia coli Proteinsrac1 GTP-Binding ProteinRAC1 protein, humanRNA, Small InterferingSEC Translocation ChannelsCNF1 toxinHACE1mycolactoneRac1Rho GTPasesSec61 translocon

Identifiers

PMID41051206
PMCPMC12607883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.