ReviewCurrent opinion in pediatrics2025
Early-life viral infections and asthma: new cells and ideas.
Review in Current opinion in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purpose of reviewAsthma is among the most common conditions managed by pediatricians. This review summarizes recent advances in our immunologic understanding of asthma, focusing on cell types implicated in pathogenesis outside of the Th2 paradigm. Early-life respiratory viral infections are a key risk factor for the development of pediatric asthma. Literature detailing the epidemiologic and immunologic connection between early-life viral infections and asthma is also reviewed. RECENT
findingsAsthma is an umbrella term used clinically, but the underlying immune mechanisms can be highly variable. These differing endotypes of asthma can be driven by distinct granulocyte, CD4 + T-cell, and innate-cell subsets, all with therapeutic implications. Early-life viral infection is a well described risk factor for asthma development. Understanding the differences in the immune system early in life, focused on the lung milieu, has shed light on the mechanisms connecting these two conditions. SUMMARY: Early-life respiratory viral infections and asthma have high prevalence in pediatrics, with the former raising the risk for the latter. Understanding the immunologic mechanisms is critical in understanding this connection. Further, our understanding of the drivers of asthma in pediatrics has expanded beyond the canonical pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.