Evidence map›Paper›PMID 41051064›Full record

ArticleThe Journal of physiology2025

Beat-to-beat QT interval variability as a tool to detect the underlying cellular mechanisms of arrhythmias.

Daisuke Sato, Bence Hegyi, Crystal M Ripplinger, Donald M Bers

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daisuke SatoDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID https://orcid.org/0000-0001-9341-0970
Bence HegyiDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID https://orcid.org/0000-0003-3113-221X
Crystal M RipplingerDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID https://orcid.org/0000-0002-9908-4106
Donald M BersDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID https://orcid.org/0000-0002-2237-9483

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
The Role of Adrenergic Stimulation in ArrhythmogenesisR01HL111600 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal May Ripplinger · 2012 to 2026
$7.1M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
Modelling structural and functional heterogeneity in heart failure reveals arrhythmic impactR01HL149349 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, SATO, DAISUKE · 2019 to 2022
$1.6M
Sex-dependent regulation of cardiac cAMP, ECC, and arrhythmia by phosphodiesterasesR01HL179122 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Crystal May Ripplinger, YANG Kevin XIANG · 2025 to 2026
$1.3M
American Heart Association 23CDA1051603NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL111600NHLBI NIH HHS R01 HL142282NHLBI NIH HHS R01 HL149349NHLBI NIH HHS R01 HL179122NIH HHS P01-HL141084NIH HHS R01HL111600NIH HHS R01HL142282NIH HHS R01HL149349
6 · The paper itself

Abstract

Increased beat-to-beat QT interval variability (QTV) on the electrocardiogram (ECG) has been associated with arrhythmia risk and sudden cardiac death. However, the underlying mechanisms driving increased QTV are not fully understood. Our previous work showed that membrane voltage instability is a major contributor to QTV. In this study, we investigated how intracellular calcium (Ca

Indexed as

alternansintracellular calcium instabilitymembrane voltage instabilitypersonalized medicineQT interval variability

Identifiers

PMID41051064
PMCPMC13690427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.