Evidence map›Paper›PMID 41051019›Full record

ArticleAIDS care2026

Self-reported sleep quality and frailty in middle-aged people living with HIV in an African setting: a pilot study.

Xi Zheng, Ruixue Cai, Chenlu Gao, Ponego Ponatshego, Lei Gao, Monty A Montano, Kun Hu, Mosepele Mosepele, Peng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Xi ZhengDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ruixue CaiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Chenlu GaoDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ponego PonatshegoDepartment of Internal Medicine, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
Lei GaoDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Monty A MontanoDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kun HuDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mosepele MosepeleDepartment of Internal Medicine, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
Peng LiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
HIV and Aging Research Consortium (HARC)R33AG067069 · NIA · UNIVERSITY OF WASHINGTON · PI STEVEN N. AUSTAD, Heidi M. Crane · 2020 to 2026
$4.8M
Integrative Motor Activity Biomarker for the Risk of Alzheimer's RiskRF1AG064312 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2019 to 2019
$3.6M
Fractal motor activity regulation and the risk for Alzheimers disease in middle-to-old aged adultsRF1AG059867 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2018 to 2018
$2.7M
Circadian Multiscale Activity Regulation and the Risk for Delirium in Elderly Hospitalized PatientsR03AG067985 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GAO, LEI · 2020 to 2021
$268k
NIAID NIH HHS P30 AI060354NIA NIH HHS R03 AG067985NIA NIH HHS R33 AG067069NIA NIH HHS RF1 AG059867NIA NIH HHS RF1 AG064312
6 · The paper itself

Abstract

People living with HIV (PLWH) are at increased risk of frailty, yet the role of sleep disturbances in this risk remains underexplored. In this cross-sectional study, we aimed to evaluate self-reported sleep quality in PLWH and relevance to frailty in a high HIV-prevalence setting within Africa. We enrolled 50 PLWH on suppressive antiretroviral therapy (age: 56.9 ± 4.4 years; 26 females) and 50 matched HIV-seronegative controls (age: 56.6 ± 4.3 years; 24 females) in Botswana. Sleep quality was scored subjectively as "good" or "poor" based on participants' responses to two self-reported sleep questions. The frailty index was constructed based on thirty-three health deficits related to body mass index, waist circumference, physical activity, emotional status, and fatigue, and scored ranging between 0 (no deficit present) and 1 (all deficits present). PLWH displayed a 2.88-fold increase in odds of having poor sleep than controls (95% CI: 1.22-6.79,

Indexed as

FrailtyHIV InfectionsSleep QualitySleep Wake DisordersAdultBody Mass IndexBotswanaCase-Control StudiesCross-Sectional StudiesFatigueFemaleHumansMaleMiddle AgedPilot ProjectsPrevalenceagingHIV comorbiditiesholistic healthMulti-morbiditySDG 3: Good health and well-beingsleep

Identifiers

PMID41051019
PMCPMC12826803

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.