Evidence map›Paper›PMID 41051006›Full record

ArticleAdvanced healthcare materials2026

ROS-Triggered Microgels for Programmable Drug Release in Volumetric Muscle Loss Repair.

Seungjun Lee, Goeun Choe, Junghyun Kim, Junggeon Park, Jia Yi Erica Kok, Jae Young Lee

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seungjun LeeSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.
Goeun ChoeSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.
Junghyun KimSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.
Junggeon ParkSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.
Jia Yi Erica KokSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.
Jae Young LeeSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.ORCID 0000-0003-4493-2494

Funding

InnoCORE program of the Ministry ofScience and ICT GISTInnoCOREKH0830Ministry of Science, ICT, and Future Planning RS-2022-NR067329Ministry of Science, ICT, and Future Planning RS-2024-00449435National Research Foundation of Korea
6 · The paper itself

Abstract

Volumetric muscle loss (VML), frequently resulting from traumatic or surgical damage, causes significant muscle mass depletion and fibrosis, and presents major challenges to effective regeneration. In this study, reduced graphene-containing hyaluronic acid microgels (rGHMs) are developed as a multifunctional platform for reactive oxygen species (ROS)-scavenging and ROS-responsive drug delivery to treat VML. The rGHMs are synthesized via a water-in-oil emulsion and subsequent chemical reduction. rGHMs demonstrate superior antioxidative capability, curcumin loading efficiency, and ROS-mediated drug release properties compared to HA microgels (HMs) and unreduced graphene-oxide containing HA microgels (GHMs). In particular, curcumin-loaded rGHMs (Cur/rGHMs) significantly facilitate curcumin release with a 2.6-fold increase under 1 mm H

Indexed as

CurcuminMicrogelsMuscle, SkeletalReactive Oxygen SpeciesAnimalsCell LineDrug Delivery SystemsDrug LiberationHyaluronic AcidHydrogen PeroxideMiceRegenerationCurcuminHyaluronic AcidHydrogen PeroxideMicrogelsReactive Oxygen Speciescurcumingraphene oxidehyaluronic acidmicrogelvolumetric muscle loss

Identifiers

PMID41051006
PMCPMC12817110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.