Evidence map›Paper›PMID 41050941›Full record

ArticleFrontiers in lab on a chip technologies2024

Reproductive organ on-a-chip technologies and assessments of the fetal-maternal interface.

Hannah A Richards, Alison J Eastman, Dusty R Miller, David E Cliffel

Abstract read
In one paragraph

Article in Frontiers in lab on a chip technologies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hannah A RichardsDepartment of Chemistry, Vanderbilt University, Nashville, TN, United States.
Alison J EastmanDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, United States.
Dusty R MillerDepartment of Chemistry, Vanderbilt University, Nashville, TN, United States.
David E CliffelDepartment of Chemistry, Vanderbilt University, Nashville, TN, United States.

Funding

TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
Instrumenting the Fetal Membrane on a ChipR01HD102752 · NICHD · VANDERBILT UNIVERSITY · PI CLIFFEL, DAVID E · 2020 to 2023
$2.5M
NICHD NIH HHS R01 HD102752NIEHS NIH HHS T32 ES007028
6 · The paper itself

Abstract

In this review, we discuss recent reproductive organ-on-a-chip (OoC) experiments that encompass multiple target areas of investigation, including model fabrication strategies, transport mechanisms, and immunology. We highlight fetal membrane and placental biology, OoC history and background, and the designs of reproductive OoC platforms. Reproductive OoC designs include fetal membrane models such as the Fetal Membrane-on-a-chip (FMOC) and others, placental models such as the placenta on-a-chip, and full reproductive tract models such as EVATAR. Diverse fabrication strategies and the integration of multiple model materials are explored. OoC samples can be analyzed with many analytical techniques, including mass spectrometry, fluorescence microscopy, ELISAs, impedance spectroscopy, and electrochemical techniques. The future of reproductive OoC models is a promising technology for advancing preterm birth (PTB) research, pharmacology studies, and fertility technologies.

Indexed as

female reproductive tractfetal membrane on-a-chipfetal membranesmicrofluidicorgan-on-chipplacenta

Identifiers

PMID41050941
PMCPMC12490809

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.