Evidence map›Paper›PMID 41050879›Full record

ArticleContemporary clinical trials communications2025

Rationale and protocol for a prospective clinical trial enrollment improvement hybrid study within a trial.

Patrick Lewicki, Sabrina Clark, Elaina Shoemaker, Bingkai Wang, Jerison Ross, Stephanie Daignault-Newton, Noelle Carlozzi, Adam Martin-Schwarze, William Meurer, Anne Sales and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06465667 (Improving Engagement With a Process Measure Dashboard Through Precision Feedback), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06465667 nacompletednot on this map

Improving Engagement With a Process Measure Dashboard Through Precision Feedback

TypeinterventionalSponsorUniversity of MichiganRan2024 to 2025Enrolled100ConditionsBehaviorArmsDashboard, Precision Feedback Push
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Patrick LewickiDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Sabrina ClarkDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Elaina ShoemakerDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Bingkai WangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Jerison RossDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Stephanie Daignault-NewtonDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Noelle CarlozziDepartment of Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI, USA.
Adam Martin-SchwarzeDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
William MeurerDepartment of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.
Anne SalesDepartment of Family and Community Medicine, University of Missouri Sinclair School of Nursing, Columbia, MO, USA.
Khurshid GhaniDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Casey DauwDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Kristian StenslandDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.

Funding

Advanced Training in Urologic OncologyT32CA180984 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ganesh S Palapattu, VAHAKN B SHAHINIAN · 2014 to 2026
$3.4M
NCI NIH HHS T32 CA180984
6 · The paper itself

Abstract

Introduction: Enrollment to clinical trials is challenging, and few evidence-based interventions to improve enrollment exist. Provider-facing advertising campaigns could help increase enrollment, but this type of intervention has not been prospectively evaluated in a clinical trial. Methods: We designed a randomized clinical trial to evaluate the effect of a month-long email advertising campaign on enrollment to a clinical trial. This hybrid implementation-effectiveness Study Within a Trial tested the effect of precision audit and feedback techniques enrollment effectiveness outcomes (enrollment) and measured implementation outcomes (email opens, link clicks). This design is an application of a Study Within a Trial (SWAT) to evaluate an intervention intended to improve enrollment. The goal of this study was to inform both this advertising campaign and refine SWAT methods for evaluating future trial improvement interventions. Discussion: This Study Within a Trial provides preliminary data on the effectiveness of email advertising campaigns for improving clinical trial enrollment. Additionally, the infrastructure built through this SWAT will inform future studies of clinical trial enrollment improvement. This protocol can serve as a template for other investigators seeking to evaluate enrollment improvement interventions.

Identifiers

PMID41050879
PMCPMC12495046

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