ArticleBioMed research international2025
Serum Anti-Erythropoietin Autoantibodies and Their Association With Younger Age in Paediatric Malaria Cases.
Article in BioMed research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Serum Anti-Erythropoietin Autoantibodies and Their Association With Younger Age in Paediatric Malaria Cases.BioMed research international · 2025Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Malaria remains a major public health concern, particularly among children under 5 years in the WHO African Region. Malarial anaemia is a common complication in this population. Factors that are associated with the development of malarial anaemia include haemolysis, dyserythropoiesis, erythrophagocytosis and bone marrow suppression, with studies reporting varying erythropoietin (epo) responses to severe anaemia. Studies on anti-epo antibodies being linked to malarial anaemia have yielded conflicting results, associated with malarial anaemia in pregnant women but not in children. This study sought to investigate anti-epo antibody production in children with malaria and explore their association with malarial anaemia. Methodology: The study recruited 90 children aged 1-10 years in Tano North Municipality, Ghana. Of these, 60 children diagnosed with malaria (30 with anaemia and 30 without anaemia) formed the case group, while 30 healthy children served as the control group. Venous blood samples were collected into K Results: In all, anti-epo antibodies were detected in 5.6% of participants who had malaria, with none of the controls being positive for the antibodies. However, the difference in anti-epo antibody positivity between the two groups was not statistically significant. Within the subgroup of 30 malarial anaemia patients, 5.0% had anti-epo antibodies compared to 3.37% within the subgroup of malaria without anaemia ( Conclusion: Anti-epo antibody production is not linked to
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