Evidence map›Paper›PMID 41050679›Full record

ArticleFrontiers in immunology2025

A nanodiamond-formulated plant protein induces robust immunity against porcine epidemic diarrhea virus in piglets.

Thuong Thi Ho, Hoai Thu Tran, Phuong Minh Thi Nguyen, Huyen Thi Bui, Hien Thu Thi Nguyen, Thao Bich Thi Le, Minh Dinh Pham, Wesley Wei-Wen Hsiao, Dai Huu Nguyen, Ha Hoang Chu and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Thuong Thi HoInstitute of Biology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Hoai Thu TranInstitute of Biology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Phuong Minh Thi NguyenInstitute of Biology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Huyen Thi BuiInstitute of Biology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Hien Thu Thi NguyenInstitute of Biology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Thao Bich Thi LeInstitute of Biology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Minh Dinh PhamInstitute of Biology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Wesley Wei-Wen HsiaoDepartment of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Dai Huu NguyenCNC Veterinary Medicine Trading and Production Joint Stock Company,, Ha Noi, Vietnam.
Ha Hoang ChuInstitute of Biology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Ngoc Bich PhamInstitute of Biology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Hang Thu Thi HoangInstitute of Biology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) continues to be a major infectious threat in swine, especially endangering piglets. The COE and S1D domains have been identified as crucial antigens suitable for designing subunit vaccines. Nanodiamonds (NDs), owing to their biocompatibility, large surface area, and modifiable surfaces, have gained interest as novel carriers to improve recombinant protein vaccines. In this study, we transiently expressed a COE-S1D fusion protein containing the GCN4pII motif (COE-S1D-pII) in

Indexed as

Coronavirus InfectionsNanodiamondsPlant ProteinsPorcine epidemic diarrhea virusSwine DiseasesViral VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralFemaleNicotianaSwineAntibodies, NeutralizingAntibodies, ViralNanodiamondsPlant ProteinsViral VaccinesCOE-S1D-pII proteinimmune responsenanodiamondPEDVpigletsvaccine

Identifiers

PMID41050679
PMCPMC12491242

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.