Evidence map›Paper›PMID 41050652›Full record

ArticleFrontiers in immunology2025

DEFA5-producing CD4

Kai Zhuang, Mengjun Li, Yalan Wu, Yi Luo, Jian Song, Sze Chun Leo Chan, Jinmei Li, Ziying Chen, Yulin Ouyang, Yongliang Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kai ZhuangState Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, China.
Mengjun LiState Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yalan WuState Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yi LuoState Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, China.
Jian SongState Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, China.
Sze Chun Leo ChanDepartment of Microbiology and Immunology, and Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jinmei LiState Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, China.
Ziying ChenSchool of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yulin OuyangSchool of Pharmaceutics, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yongliang ZhangDepartment of Microbiology and Immunology, and Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ying LinDepartment of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Huanhuan LuoState Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale: Atopic dermatitis (AD) is associated with various gastrointestinal symptoms, yet the underlying mechanisms remain poorly understood. This study aimed to investigate intraepithelial lymphocytes (IELs) in the intestines of AD patients and their potential contribution to intestinal inflammation. Methods: Single-cell RNA sequencing was utilized to analyze the immune cell composition in the ileum of adult AD patients with severe symptoms. Laser confocal microscopy, Western blot, polymerase chain reaction and adoptive T cell transfer experiments were carried out to investigate the phenotypes of IELs and contribution of CD4 Results: A distinct group of DEFA5-expressing CD4 Conclusions: AD is linked to an increase in intestinal DEFA5-expressing CD4

Indexed as

CD4-Positive T-LymphocytesDermatitis, AtopicIntestinal MucosaIntraepithelial LymphocytesAdultAnimalsDisease Models, AnimalFemaleHumansInflammationMaleMiceMiddle Agedatopic dermatitisDEFA5intraepithelial lymphocytesPPARγsingle-cell RNA sequencing

Identifiers

PMID41050652
PMCPMC12491060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.