ReviewNature and science of sleep2025
Molecular and Clinical Perspectives on the Regulation of Sleep and Uric Acid Metabolism.
Review in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Integrative Bioinformatics Prioritizes theBiology · 2026Article
- Therapeutic potential of traditional Chinese medicine for hyperuricemia: mechanistic insights and clinical prospects.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uric acid, the end product of purine metabolism, is closely associated with metabolic disorders, including gout and metabolic syndrome. Emerging evidence highlights a bidirectional relationship between uric acid metabolism and sleep regulation. Elevated uric acid levels can adversely affect sleep quality via oxidative stress and neuroinflammatory pathways, while sleep deprivation may promote uric acid synthesis and impair its excretion. This reciprocal interaction may form a vicious cycle, potentially accelerating the onset and progression of various metabolic diseases. This review summarizes recent clinical and experimental findings, focusing on the molecular mechanisms underlying the bidirectional regulation between uric acid metabolism and sleep. The implications of this relationship in the pathophysiology of metabolic disorders are discussed. Understanding this interplay underscores the importance of targeting uric acid levels and sleep quality as integrated strategies for managing metabolic diseases. These insights provide a foundation for the development of novel therapeutic interventions designed to enhance clinical outcomes in metabolic syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.