Evidence map›Paper›PMID 41050633›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

Antithrombotic strategies and outcomes in neonates and infants with cardiac shunts: a systematic review and meta-analysis.

Amy L Kiskaddon, Neil A Goldenberg, Marisol Betensky, Joshua W Branstetter, Dina Ashour, Pamela Williams, Arabela C Stock, Michael Silvey, Therese M Giglia, Nhue L Do and 1 more

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Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Amy L KiskaddonDivisions of Hematology and Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Neil A GoldenbergInstitute for Clinical and Translational Research, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
Marisol BetenskyCancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
Joshua W BranstetterDepartment of Pharmacy, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Dina AshourInstitute for Clinical and Translational Research, Epidemiology and Biostatistics Shared Resource, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
Pamela WilliamsMedical Library, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
Arabela C StockHeart Institute, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
Michael SilveyDivision of Hematology/Oncology/Bone Marrow Transplant, Department of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri, USA.
Therese M GigliaDivision of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nhue L DoAdvocate Children's Heart Institute, Advocate Children's Hospital, Chicago, Illinois, USA.
Cardiac Disease Thrombosis and Hemostasis Working Party of the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiac shunt thrombosis in neonates and infants remains a concern for shunt failure and mortality. The optimal strategy for thromboprophylaxis remains unknown. Objectives: This systematic review aims to characterize antithrombotic strategies and outcomes in neonates and infants with a cardiac shunt. Methods: MEDLINE, Embase, and Cochrane CENTRAL were searched from inception through July 2024 for studies reporting shunt thrombosis prevalence among infants who received a cardiac shunt. We estimated the pooled prevalence of shunt thrombosis using random-effects meta-analysis. In the subgroup analysis, we evaluated the effects of shunt type and antithrombotic strategies on shunt thrombosis prevalence. Results: A total of 39 studies (29 retrospective, 10 prospective) were included, totaling 4735 patients. The most common shunt type was the modified Blalock-Taussig ( Conclusions: This systematic review of nearly 5000 neonates and infants reveals a high rate of mortality associated with shunt thrombosis. Collaborative prospective studies are warranted to evaluate antithrombotic regimen-outcome relationships and prognostic factors for shunt thrombosis and bleeding outcomes in these children.

Indexed as

cardiac shuntcongenital heart diseaseinfantneonateshunt thrombosisthromboprophylaxis

Identifiers

PMID41050633
PMCPMC12494822

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.