Radiologically Measured Renal Pelvis Urine Density Is Associated with Severe Infectious Complications After Ureteroscopy for Ureteral Stones: A Post Hoc Analysis of a Multicenter Prospective Study.

Zichuan Yao, Po-Hua Lin, Kaiqi Zhang, Hongliang Ji, Shiyu Song, Fei Wu, Hanfeng Xu, Zhen Liu

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Article in European urology open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

Of the manuscript: predictive value of renal parenchyma and pelvic urine density on preoperative non-contrast CT in systemic inflammatory response syndrome (SIRS) after semi-rigid ureteroscopy.Urolithiasis · 2025
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8 authors.

Zichuan YaoDepartment of Urology, Shengjing Hospital of China Medical University, Shenyang, China.

Po-Hua LinDepartment of Urology, Shengjing Hospital of China Medical University, Shenyang, China.

Kaiqi ZhangDepartment of Urology, Shengjing Hospital of China Medical University, Shenyang, China.

Hongliang JiThe Fifth Hospital of Liaoyang City, Liaoyang, China.

Shiyu SongLuhe Hospital of Yingkou City, Yingkou, China.

Fei WuDepartment of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

Hanfeng XuDepartment of Urology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Zhen LiuDepartment of Urology, The People's Hospital of Liaoning Province, The People's Hospital of China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objective: Finding reliable and easy-to-obtain indicators of severe infectious complications after ureteroscopy represents a major clinical need. This study aimed to assess the association between Hounsfield units (HUs) in renal pelvis urine and severe infectious complications in patients with ureteral stones and asymptomatic hydronephrosis following ureteroscopy. Methods: In this post hoc analysis of a multicenter prospective trial, renal pelvis urine density (RPUD) was measured via non-contrast-enhanced computed tomography. Severe complications (septic shock, urosepsis, and systemic inflammatory response syndrome) were recorded. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by multivariable logistic regression. Key findings and limitations: Among 601 patients, 9.5% (57/601) developed severe infectious complications. After adjustment, each one HU unit increase in RPUD was associated with 54% higher odds of severe infectious complications (adjusted OR = 1.54; 95% CI: 1.37-1.73; Conclusions and clinical implications: This study demonstrates a positive linear association between renal pelvis urine HU values and severe infectious complications after ureteroscopy, independent of comprehensive patient and stone characteristics. Patient summary: We found that higher urine density in the renal pelvis (measured by a computed tomographic scan) is significantly associated with the incidence of severe infectious complications after ureteroscopy for ureteral stones.

Indexed as

Hounsfield unitInfectious complicationRenal pelvis densityUreteroscopic lithotripsyUrosepsis

Identifiers

PMID41050596

DOI10.1016/j.euros.2025.09.002

PMCPMC12494560

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