Evidence map›Paper›PMID 41050552›Full record

ArticleAmerican journal of preventive cardiology2025

Relationship between interleukin-6, coronary artery calcium and risk of heart failure: Insights from MESA.

Muhammad Imtiaz Ahmad, Parag A Chevli, Saeid Mirzai, Rishi Rikhi, Neha Pagidipati, Leandro Slipczuk, Moyses Szklo, Michael D Shapiro

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Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muhammad Imtiaz AhmadDepartment of Internal Medicine, Section on Hospital Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Parag A ChevliCenter for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Saeid MirzaiCenter for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Rishi RikhiCenter for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Neha PagidipatiDepartment of Internal Medicine, Cardiology Section, Duke University School of Medicine, Durham, NC, USA.
Leandro SlipczukCardiology Division, Montefiore Health System/Albert Einstein College of Medicine, New York, NY, USA.
Moyses SzkloDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Michael D ShapiroCenter for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study investigated the joint association of interleukin-6 (IL-6) and coronary artery calcium (CAC) with the risk of heart failure (HF). Methods and Results: Among 6592 participants in the Multi-Ethnic Study of Atherosclerosis (MESA), individuals were categorized into four groups based on CAC (0 vs >0) and IL-6 (cutoff 1.32 pg/mL via Youden's index): low CAC/low IL-6 (reference), low CAC/high IL-6, high CAC/low IL-6, and high CAC/high IL-6. Multivariable Cox models were used to assess the risk of total heart failure (HF), HF with reduced ejection fraction (HFrEF), and HF with preserved ejection fraction (HFpEF). Compared to the reference group, the hazard ratios (HRs) for total HF were 1.61 (95 % CI, 1.12-2.31) for high IL-6, 1.56 (95 % CI, 1.11-2.20) for high CAC, and 2.00 (95 % CI, 1.43-2.80) when both were elevated (multiplicative interaction Conclusions: Combined elevation of IL-6 and CAC was associated with increased HFrEF risk, with significant additive and multiplicative interactions. For HFpEF, combined elevation conferred less risk than either alone. Inflammation modifies the CAC-HFrEF relationship and merits further study.

Indexed as

Coronary artery calciumHeart failureInflammationMESA

Identifiers

PMID41050552
PMCPMC12495076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.