Trial reportNeuropsychiatric disease and treatment2025
Disruptions of p11 (S100A10) and HPA Axis Homeostasis Participate in the Major Depressive Disorder (MDD) Especially in Female Patients.
Trial report in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Objective: Patients suffering from major depressive disorder (MDD) commonly exhibit abnormal p11 (S100A10) and dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis. This study was aimed to quantify peripheral p11, cortisol (COR), and adrenocorticotropic hormone (ACTH) levels and further revealed the possible mechanisms of MDD and antidepressant response. Methods: A total of 60 MDD inpatients and 67 healthy controls (HC) were recruited in this study. Demographic characteristics and neuropsychological assessment including Hamilton rating scale for depression-17 (HAMD-17), Hamilton anxiety rating scale (HAMA), Snaith-Hamilton pleasure scale (SHAPS) and temporal experience of pleasure scale (TEPS) were collected. A main antidepressant was utilized after the patients were enrolled (T0) and at two week follow-up (T2). Peripheral p11 levels including monocyte (MO), natural killer (NK), T-cell, COR, and ACTH were measured by multicolor flow cytometry and enzyme-linked immunosorbent assay at T0 and T2. Results: CD4+T p11, COR and ACTH were significantly different between the MDD and HC groups at T0 (all Conclusion: Baseline p11 levels may serve as a peripheral blood biomarker for female depressive patients and further provide more insight into the pathological mechanisms of MDD.
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