Evidence map›Paper›PMID 41050479›Full record

ArticleRheumatology and immunology research2025

Proceedings of cell-free noncoding RNA biomarker studies in liquid biopsy.

Yumin Zhu, Fengping Wu, Kangping Liu, Shaozhen Xing, Chun Ning, Meng Ning, Heyue Jin, Yun Shao, Zhenye Zhu, Hongke Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology and immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yumin ZhuMedical School, Nanjing University, Nanjing 210093, Jiangsu Province, China.
Fengping WuMedical School, Nanjing University, Nanjing 210093, Jiangsu Province, China.
Kangping LiuDepartment of Maternal & Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui Province, China.
Shaozhen XingMOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Chun NingDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education Key Laboratory of Rheumatology and Clinical Immunology, Beijing 100730, China.
Meng NingTianjin Third Central Hospital, Tianjin 300170, China.
Heyue JinDepartment of Maternal & Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui Province, China.
Yun ShaoDepartment of Maternal & Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui Province, China.
Zhenye ZhuDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education Key Laboratory of Rheumatology and Clinical Immunology, Beijing 100730, China.
Hongke WangMOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Binbin ShiMOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Yajin MoMOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Xinping TianDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education Key Laboratory of Rheumatology and Clinical Immunology, Beijing 100730, China.
Mengtao LiDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education Key Laboratory of Rheumatology and Clinical Immunology, Beijing 100730, China.
Jiuliang ZhaoDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education Key Laboratory of Rheumatology and Clinical Immunology, Beijing 100730, China.ORCID https://orcid.org/0000-0001-9308-2858
Zhi John LuMOE Key Laboratory of Bioinformatics, State Key Lab of Green Biomanufacturing, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID https://orcid.org/0000-0003-4751-9400
Ning GuMedical School, Nanjing University, Nanjing 210093, Jiangsu Province, China.ORCID https://orcid.org/0000-0003-0047-337X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid biopsy has great application value in the field of precision medicine because of its non-invasiveness, sensitivity and dynamics. Cell-free RNA molecules are one of the emerging biomarkers that can be used for liquid biopsy, and cell-free non-coding RNAs have become main RNA molecular markers because of their high abundance and stability, as well as their regulatory roles in basic development. It provides clues for the diagnosis, prognosis and monitoring of a variety of complex diseases, including rheumatic and immune diseases. This article describes the characterization of cell-free non-coding RNAs and bioinformatics strategies, and summarizes cell-free non-coding RNA biomarkers associated with rheumatic and immune diseases. Prospects and reflections are made on the further research and clinical application of cell-free RNA markers.

Indexed as

cell-freedisease biomarkerliquid biopsynoncoding RNAtranscriptome

Identifiers

PMID41050479
PMCPMC12495990

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.