Evidence map›Paper›PMID 41050425›Full record

ArticleGynecologic oncology reports2025

Cervical HPV 18 detection is associated with high-grade cervical dysplasia in Kenyan and Ugandan women living with HIV.

Miriam Nakalembe, Collins Mpamani, Jane Namugga, Carolyn Nakisige, Grace Banturaki, Phillip Tonui, Peter Itsura, Omenge Orang'o, Kapten Muthoka, Anthony Ngeresa and 5 more

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Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Miriam NakalembeDepartment of Obstetrics and Gynaecology, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Collins MpamaniDepartment of Obstetrics and Gynaecology, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Jane NamuggaDepartment of Obstetrics and Gynaecology, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Carolyn NakisigeDepartment of Obstetrics and Gynaecology, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Grace BanturakiDepartment of Obstetrics and Gynaecology, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Phillip TonuiDepartment of Reproductive Health, Moi University, Eldoret, Kenya.
Peter ItsuraDepartment of Reproductive Health, Moi University, Eldoret, Kenya.
Omenge Orang'oDepartment of Obstetrics and Gynecology, Aga Khan University, Medical College, Kenya.
Kapten MuthokaAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
Anthony NgeresaAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
Beverly MusickDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA.
Aaron ErmelDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Patrick LoehrerDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Darron R BrownDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Yan TongDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Cervical cancer, caused by "high-risk" (HR) HPV, is the most common malignancy and the leading cause of cancer deaths among women living in Kenya and Uganda. Women living with HIV (WLWH) are at a high risk for HR-HPV infection. This longitudinal, observational cohort analysis was conducted to identify factors that are important among WLWH in prediction of cervical intraepithelial neoplasia grades 2 or 3 (CIN2/3). Methods: Data of this analysis was based on a study of HPV natural history and cervical cancer among Kenyan and Ugandan WLWH. Demographic, behavioral and biological data were collected; HR-HPV DNA testing of cervical swabs was performed (Roche Cobas Assay); all WLWH underwent cervical biopsy on two occasions. Results: Of 114 WLWH enrolled, the median age was 38.2 years. All WLWH were receiving ART during the study. CIN2/3 was found in 13 (11.4 %) WLWH; HPV 16 was detected in 10 (8.8 %); HPV 18 in 11 (9.6 %), and Non-16/18 HR-HPV in 62 (54.4 %). Aflatoxin exposure was not associated with CIN2/3 in this analysis. A multivariable logistic regression found that cervical detection of HPV 18 was significantly associated with CIN2/3 (OR = 6.36, 95 % CI = 1.36-29.75, p = 0.019), after adjusting for the effects of HIV viral load, CD4 counts, and Non-16/18 HR-HPV detection. Conclusions: CIN2/3 was detected in 11.4% of WLWH; HPV 18 detection in cervical swabs was strongly associated with CIN2/3. Larger studies among WLWH are needed to determine optimal approaches for screening and treatment to prevent cervical cancer.

Indexed as

Cervical intraepithelial neoplasiaHPV 18Kenyan womenUgandan womenWomen living with HIV

Identifiers

PMID41050425
PMCPMC12495285

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