SynthesisFrontiers in pharmacology2025
Efficacy and safety of Traditional Chinese Medicine in alleviating symptoms associated with myocardial bridge: a systematic review and meta-analysis.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: With the advancement of technology, the detection rate of myocardial bridge (MB) has gradually increased and attracted attention. However, management options for symptomatic MB are limited, and Traditional Chinese Medicine (TCM) has emerged as a potential complementary approach for managing symptoms in MB patients. This study conducted a meta-analysis by pooling data from clinical randomized controlled trials (RCTs) to assess the efficacy and safety of TCM in alleviating symptoms in patients with MB. Methods: RCTs of TCM for MB were searched in PubMed, Embase, Web of Science, Cochrane Library, CBM, Wanfang, VIP, and CNKI databases from their inception to 1 April 2025. Patients diagnosed with MB Results: A total of 18 publications were included, containing 1,224 participants, with 613 in the intervention group and 611 in the control group. Meta-analysis results showed that TCM significantly improved angina efficacy [RR = 1.30, 95% CI (1.21, 1.40), Conclusion: TCM combined with biomedicine significantly improves angina symptoms, reduces attack frequency, enhances electrocardiographic parameters, alleviates TCM syndrome scores, and improves quality of life in patients with myocardial bridge, with a favorable safety profile. Crucially, TCM monotherapy showed no significant benefits for objective ischemia markers (ECG) or TCM syndrome scores, underscoring its role as a complementary adjunct rather than an alternative to standard care. However, these findings should be interpreted with caution due to the limited number of included RCTs, poor quality, small sample size, and single-center studies. Future large-scale, high-quality RCTs are warranted to confirm these results and further evaluate the efficacy and safety of TCM for symptom management in MB. Systematic Review Registration: identifier CRD420251000868.
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