Evidence map›Paper›PMID 41050347›Full record

ArticleSchizophrenia research. Cognition2026

Divergent age-related cognitive impairments in first-episode psychosis.

ChengFei Duan, ChunHua Cao, MingLiang Ju, YanYan Wei, XiaoChen Tang, LiHua Xu, HuiRu Cui, YingYing Tang, ZhengHui Yi, Xin Wei and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research. Cognition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

ChengFei DuanDepartment of Psychiatry, The Eighth People's Hospital of Zhengzhou, Zhengzhou, China.
ChunHua CaoShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
MingLiang JuShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Neuroregulation Center, Shanghai, 200030, China.
YanYan WeiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Neuroregulation Center, Shanghai, 200030, China.
XiaoChen TangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Neuroregulation Center, Shanghai, 200030, China.
LiHua XuShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Neuroregulation Center, Shanghai, 200030, China.
HuiRu CuiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Neuroregulation Center, Shanghai, 200030, China.
YingYing TangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Neuroregulation Center, Shanghai, 200030, China.
ZhengHui YiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Neuroregulation Center, Shanghai, 200030, China.
Xin WeiThe Brain Hospital of Guangxi Zhuang Autonomous Region, LiuZhou, China.
JiJun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Neuroregulation Center, Shanghai, 200030, China.
TianHong ZhangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Neuroregulation Center, Shanghai, 200030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cognitive impairment is a core feature of first-episode psychosis (FEP), but its age-associated cognitive patterns remain unclear. Prior studies suggest FEP is associated with baseline cognitive deficits and accelerated decline, yet inconsistencies exist regarding whether cognitive aging in FEP mirrors or diverges from healthy aging. Methods: We compared 378 drug-naive FEP patients and 477 healthy controls (HC) using the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB). Clinical symptoms were evaluated via the Positive and Negative Syndrome Scale (PANSS). Age-correlations with cognitive domains were analyzed via Pearson's coefficients and Fisher's z-transformation. Results: FEP patients showed significant deficits across all cognitive domains (all Conclusions: FEP disrupts normative cognitive aging patterns, characterized by atypical decline and compensatory improvements. These findings highlight the need for longitudinal studies to clarify mechanisms and inform age-adapted interventions.

Indexed as

AgeFirst-episodeNeurocognitionPsychosisSchizophrenia

Identifiers

PMID41050347
PMCPMC12493215

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.