ArticleInternational journal of clinical pediatric dentistry2025
Remineralization Potential of Casein Phosphopeptide-Amorphous Calcium Phosphate, Nanohydroxyapatite Crystals, and Bioactive Glass on Initial Enamel Lesions: A Systematic Review and Meta-analysis.
Article in International journal of clinical pediatric dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Biomimetic Enamel Remineralization in Pediatric Dentistry: From Biological Principles to Clinical Evidence.Cureus · 2026Review
- Biomimetic Strategies for Subsurface Enamel Remineralization: Depth-Dependent Effects of Biomimetic Agents Compared with Fluoride.Biomimetics (Basel, Switzerland) · 2026Article
- Contemporary biomimetic and bioactive materials in paediatric dentistry: a narrative review.The Saudi dental journal · 2026Review
- Tetracycline Enables Visualization of Remineralization Induced by Agents Penetrating Dental Enamel.Calcified tissue international · 2026Article
- Comparative Assessment of the Remineralization Potential of Five Modern Oral Health Products on Bovine Enamel.Journal of functional biomaterials · 2025Article
- Application of Amorphous Nanomaterials in Dentistry: A Comprehensive Review.Journal of functional biomaterials · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Background: Dental caries is a prevalent chronic disease among both adult and pediatric patients characterized by enamel demineralization, leading to significant oral health issues. While fluoride has been the cornerstone of caries prevention, alternative remineralizing agents such as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), nanohydroxyapatite (nHAp) crystals, and bioactive glass (BAG) are gaining attention for their potential in biomimetic enamel restoration. This systematic review and meta-analysis aim to compare the efficacy of these novel agents with conventional fluoride treatments in remineralizing initial enamel lesions (IELs). Materials and methods: This review was conducted across databases including MEDLINE, ProQuest, and Cochrane Library, covering studies from 2004 to 2024. The focus was on Results: Among the 292 identified articles, 19 met the inclusion criteria. Meta-analysis showed an overall pooled estimate of -1.31 (95% CI: -3.90 to 1.28) in favor of fluoride, though not statistically significant ( Conclusion: nHAp show promise as alternatives to fluoride for IEL remineralization in both pediatric and adult patients. However, the evidence quality is weak due to high heterogeneity and methodological limitations. Further How to cite this article: Santhosh VN, Ankola AV, Sankeshwari RM,
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Registered trials
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