ArticleSchizophrenia bulletin open2025
Obstacles, Opportunities, and Ethical Considerations for Genomic Investigations of Individuals Continuously Hospitalized with Treatment-resistant Schizophrenia.
Article in Schizophrenia bulletin open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The association of schizophrenia polygenic scores with continuously-hospitalized, treatment-resistant schizophrenia.Molecular psychiatry · 2026Article
- Increasing participation of people with thought disorder in clinical research.European psychiatry : the journal of the Association of European Psychiatrists · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Hypothesis: The overarching objective when studying schizophrenia is the development of generalizable knowledge that improves patient health and/or increases our comprehension of their illness. To fully achieve this objective, investigations need to reflect the Study Design: This article provides brief reviews of (1) ethical considerations when recruiting individuals with severely treatment-resistant psychotic symptoms for research, (2) the impact their condition has on decision-making capacity, and finally (3) we provide a first-hand narrative of our experience conducting a genomic study of involuntarily hospitalized individuals and the opportunities/obstacles we encountered. Study Results: Evidence from published literature shows that cognitive impairment, rather than severity of psychopathology, is the greatest threat to decisional capacity. Ethical safeguards and practical considerations have been developed, including (1) institutional/local research committee review and approval, (2) confidentiality, (3) informed consent, (4) assessment of capacity, and (5) community engagement. Our experience demonstrates that carefully selected involuntarily committed individuals can be included in research. Conclusions: With ethical safeguards, these individuals deserve the opportunity to volunteer for research regarding the mental illness that has profoundly shaped their lives-to do otherwise is discriminatory.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.