Trial reportDiabetes, metabolic syndrome and obesity : targets and therapy2025
Electroacupuncture Reduces Waistline in Patients with Abdominal Obesity: A Randomized Controlled Trial with Mechanistic Analysis of Lipidomic and Intestinal Microbiota.
Trial report in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04957134 (The Efficacy and Safety of Electro-acupuncture for Abdominal Obesity), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy and Safety of Electro-acupuncture for Abdominal Obesity: Original Study for a Multicenter, Randomized, Sham-controlled Trial
Who cites it
1 citing paper in PubMed.
- Clinical efficacy and mechanism exploration of Moxibustion for diminished ovarian reserve: a randomized controlled trial protocol.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Abdominal obesity is a major risk factor for metabolic diseases and certain cancers. Although lifestyle intervention is the cornerstone of treatment, maintaining weight reduction is challenging. Electroacupuncture (EA) has shown potential in improving abdominal obesity, but its underlying mechanisms remain unclear. Objective: This randomized controlled trial evaluates the efficacy of electroacupuncture combined with lifestyle intervention for reducing waist circumference in adults with abdominal obesity, and explores potential mechanisms through lipidomics and intestinal microbiota analyses. Methods: The studies were performed in Hubei Provincial Hospital of Traditional Chinese Medicine between July 2020 and March 2023. Sixty-eight patients with abdominal obesity and 34 matched - healthy controls (HC) were recruited. After randomization, patients with abdominal obesity received an 8-week EA treatment or sham electroacupuncture (SA) treatment followed by 24-week follow-up. The change of waistline was to evaluate the efficacy of EA. Serum and stool specimen of EA group (pre- and post-treatment) and HC were collected for lipid metabolism markers and intestinal microbiota analysis. Results: Compared with baseline, the difference of waistline between EA and SA was 7.38 (95% CI, 2.88 to 11.87; P = 0.002) cm at the end of treatment (week 8) and 8.99 (95% CI, 4.48 to 13.50; P < 0.001) cm at the end of follow-up (week 32), respectively. Lipidomic analysis indicated that some lipid species previously found to differ between patients with abdominal obesity and healthy controls showed a trend toward reversal after EA treatment. Microbiota analysis showed that EA did not significantly alter overall richness, but the abundance of certain taxa changed, particularly Trial Registration: ClinicalTrials, NCT04957134. Registered 30 June 2021, https://clinicaltrials.gov/study/NCT04957134?term=NCT04957134&rank=1. Conclusion: Our findings suggest that electroacupuncture is effective and safe in reducing waistline in patients with abdominal obesity. These results provide preliminary evidence that its benefits may be related to changes in lipid metabolism and intestinal microbiota, although further studies are warranted.
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