Evidence map›Paper›PMID 41050138›Full record

ArticleBioactive materials2026

3D-printed functionalized strontium-silk fibroin-hydroxyapatite scaffolds facilitate bone regeneration via immunomodulatory and sequential angiogenic-osteogenic coupling.

Kui Huang, Qilin Li, Yunfei Liu, Piaoye Ming, Long Bo, Qiumei Li, Rui Cai, Gang Tao, Xiaoxiao Cai, Jingang Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Harnessing strontium in regenerative dentistry: progress and perspectives.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kui HuangDepartment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, 646002, China.
Qilin LiLuzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou, 646600, China.
Yunfei LiuDepartment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, 646002, China.
Piaoye MingLuzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou, 646600, China.
Long BoState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Qiumei LiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Rui CaiLuzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou, 646600, China.
Gang TaoLuzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou, 646600, China.
Xiaoxiao CaiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Jingang XiaoDepartment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, 646002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The repair of large bone defects remains a significant clinical challenge. The development of bioactive materials for bone tissue engineering offers promising solutions to address these problems. However, the lack of vascularization and the risk of endogenous immune rejection severely hinder the application of implantable biomaterials in bone regeneration. Therefore, in this study, we synthesized a multifunctional 3D-printed biological scaffold (EP@PCL/Sr) for achieving staged vascularized bone regeneration in the immune microenvironment to promote bone defect repair. Firstly, the rough surface morphology of the EP@PCL/Sr scaffolds enhanced cell proliferation and adhesion. Furthermore, epigallocatechin-3-gallate, a surface-coating component, contributed to immune regulation. Finally, strontium-silk fibroin (Sr-SF)-modified hydroxyapatite, embedded within the PCL scaffold, released Sr and Ca ions to improve both angiogenesis and osteogenesis. Both

Indexed as

AngiogenesisBone defect repairEP@PCL/Sr scaffoldsImmune regulationOsteogenesisScavenge reactive oxygen species

Identifiers

PMID41050138
PMCPMC12495060

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.