ArticleKidney medicine2025
Severe Acute Kidney Injury Associated With Intestinal Ostomies.
Article in Kidney medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Strategies for Managing Fluids and Electrolytes in High-Output Stomas: A Systematic Review and Evidence Summary.Journal of multidisciplinary healthcare · 2026Review
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale & Objective: People with ostomies can experience high output, a risk of acute kidney injury (AKI). We evaluated patients with AKI associated with ostomies (ostomy-AKI) and compared with AKI of other etiologies (general-AKI) with the objective of describing their clinical presentation and their association with major adverse kidney events at 10 and 30-90 days (major adverse kidney events [MAKE] 10 and 30-90, respectively). Study Design: A retrospective cohort study. Setting & Participants: Conducted at the Hospital Civil of Guadalajara. We included patients with Ostomy-AKI and General-AKI. Exposures or Predictors: Ostomy-AKI. Outcomes: Describing and differentiating their clinical presentation and their association with MAKE 10 and MAKE 30-90, in addition to its individual components, as death, new requirement for dialysis, or ≥25% decline in the estimated glomerular filtration rate from baseline. Analytical Approach: Analyzed the risk by logistic regression model and a multivariate Cox proportional hazard. Results: From February 2020 to October 2023, 84 patients with ostomy-AKI and 348 with general-AKI were included. Most ostomy-AKI were male (78.7 vs 56.2%), the mean ostomy output was 980 mL/day (760-1,700), 82.9% requiring fluid adjustment. Ostomies had been created for cancer (46%) 2.3 months before AKI. The etiology of ostomy-AKI, compare to general-AKI, was more frequently due to hypovolemia (48.9% vs 24.5%) and was of greater AKI severity (stage 3, 82.9% vs 63.9%). Both groups had the same frequency of MAKE 10 (94%), and their individual components. MAKE 30-90 occurred more frequently in ostomy-AKI (65.9% vs 49.3%) as well as mortality (59.5% vs 37%), doubling this risk (OR 2.403; 95% CI, 1.090-5.299; Limitations: A retrospective cohort, residual confounding, and small sample size. Conclusions: In comparison with general-AKI, patients with ostomy-AKI present more often with hypovolemia and greater AKI stage, had a higher mortality at 30-90 day follow-up, and a 2.5-fold increase in risk of MAKE.
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