Evidence map›Paper›PMID 41050098›Full record

ArticleMaterials today. Bio2025

Sequential drug-release microsphere system for scarless wound healing.

Dong Luo, Linxue Huang, Boxiong Bai, Huiqi Zhang, Wenshang Liu, Beibei Wen, Zhengmao Lu, Xiaohui Pu, Qian Chen, Zhengyu Shen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Advancements in Functional Polymeric Scaffolds for Scar-Free Skin Regeneration.Polymer science & technology (Washington, D.C.) · 2026
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dong LuoDepartment of Dermatology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Linxue HuangDepartment of Dermatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610041, China.
Boxiong BaiInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, 215127, China.
Huiqi ZhangDepartment of Dermatology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Wenshang LiuDepartment of Dermatology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Beibei WenState Key Laboratory of Antiviral Drugs, Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, 475004, China.
Zhengmao LuDepartment of Gastrointestinal Surgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Xiaohui PuState Key Laboratory of Antiviral Drugs, Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, 475004, China.
Qian ChenInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, 215127, China.
Zhengyu ShenDepartment of Dermatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Meng LiDepartment of Dermatology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dynamic imbalance in skin wound healing is a key factor of hypertrophic scar (HS) formation. Traditional treatments often target only a certain stage of the wound healing process and fail to comprehensively address the dynamic imbalance, thus making it difficult to achieve scarless wound healing. This study developed a chronologically adaptive methacrylylated gelatin (GelMA)-based microsphere delivery system (G/E/T) that achieves comprehensive intervention in wound healing process through precisely orchestrated sequential release of epigallocatechin gallate (EGCG) and triamcinolone acetonide (TA). In vitro studies have confirmed that the G/E/T microsphere system, utilizing this sequential release mechanism, not only alleviates oxidative stress and inflammatory responses in the early stages but also persistently inhibits the excessive proliferation and migration of fibroblasts in the later phases, demonstrating stage-specific therapeutic precision. Moreover, validated through mouse full-thickness wound model and rabbit ear HS model, the system exhibited remarkable scarless healing outcomes. The "sequential release and dual-agent synergy" design paradigm provides an innovative strategy for scarless wound healing while establishing a foundational framework for developing sequential multidrug delivery systems targeting complex pathological processes.

Indexed as

EGCGGelMA microsphereScarless wound healingSequential releaseTA

Identifiers

PMID41050098
PMCPMC12494857

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.