Evidence map›Paper›PMID 41050092›Full record

ArticleMaterials today. Bio2025

Synergistic dual chemophysical FeCu-MOF scaffold with PEMF stimulation drives angiogenic-osteogenic coupling for bone regeneration.

Dongdong Guo, Wenjie Wang, Dongyang Zhao, Tianyu Chen, Xingyu Ma, Yixiao Li, Xiaojun Zhang

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Dongdong GuoDepartment of Orthopedics, Northwest University First Hospital, Xi'an, Shaanxi Province, 710043, China.
Wenjie WangKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, Shaanxi Province, 710069, China.
Dongyang ZhaoSchool of Medicine, Northwest University, Xi'an, Shaanxi Province, 710069, China.
Tianyu ChenKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, Shaanxi Province, 710069, China.
Xingyu MaSchool of Medicine, Northwest University, Xi'an, Shaanxi Province, 710069, China.
Yixiao LiSchool of Medicine, Northwest University, Xi'an, Shaanxi Province, 710069, China.
Xiaojun ZhangDepartment of Orthopedics, Northwest University First Hospital, Xi'an, Shaanxi Province, 710043, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repairing large bone defects effectively requires concurrent osteogenesis and angiogenesis, a significant challenge for conventional biomaterials often limited by suboptimal structural design and an inability to provide spatiotemporally controlled bioactive cues. Here, we report a novel chemophysical dual-responsive system rationally designed to address this osteogenic-angiogenic coupling challenge. This system integrates a structurally engineered bimetallic FeCu-metal-organic framework (FeCu-MOF) within a poly(lactic acid)/hydroxyapatite (PLA/HA) scaffold. The engineered FeCu-MOF architecture enables the programmed and sustained co-release of Fe

Indexed as

AngiogenesisBone regenerationChemophysical synergyFeCu-MOFOsteogenesisPulsed electromagnetic fields (PEMF)

Identifiers

PMID41050092
PMCPMC12489837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.